Published: 2017-01-23

Clinicopathological study of carcinoma stomach over a period of 5 years

J. Sushma, B. V. S. Kartheek, A. Bhagya Lakshmi


Background: Gastric cancer represents one of the most frequent neoplasias. Although its incidence decreased over the last few decades in industrialized countries, it still represents nowadays a major cause of death through cancer throughout the world. The purpose of this study was to identify clinicopathological parameters in gastric carcinoma.

Methods: A total of 115 gastrectomy specimen received in 5 year period at a tertiary care center was analyzed. The clinical data was recorded. After fixing the specimen in 10% formal saline for 24 hours the gross appearance of the specimen was studied. The gross findings were recorded following Borrmann classification. The tissue blocks were routinely processed and stained with H&E stain. The results were tabulated.

Results: The prevalence of gastric carcinoma was 4.46%, with male: female ratio of 3:1 and mean age of 50years.The prevalence of carcinoma stomach was more common in rural areas and poor socio economic status. Sixty percent of patients who consumed mixed diet suffered from carcinoma and 82.8% had history of intake of alcohol. Carcinoma stomach was more common in A blood group. The tumor was more common in pyloric antrum (73.04%). According to Borrmann classification type II tumour was the commonest (66.09%) of the lesions. Commonest histological pattern was adenocarcinoma; intestinal type (86.72%).

Conclusions: The prevalence of carcinoma stomach in the present study was 4.46%. High prevalence of gastric carcinoma was seen in patients with history of smoking, intake of alcohol and consumption of mixed diet. Carcinoma stomach was more common in A blood group followed by B blood group. Adenocarcinoma of intestinal type was the commonest.


Borrmann classification, Dietary habits, Gastric carcinoma, Histopathology

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Parkin DM, Pisani P, Felay J. Estimates of the world wide, incidence of eighteen major cancers in 1985. Int I Cancer. 1993;55:594-606.

Malhotra SL. Geographical distribution of gastro intestinal cancers in India with special reference to causation. GUT. 1967:361-72.

Hu B, Hajj NE, Sittler S, Lammert N, Barnes R, Ehrig AM. Gastric cancer: Classification, histology and application of molecular pathology. J Gastrointest Oncol. 2012;3(3):251-61.

Abdulkareem FB, Onyekwere CA, Awolola NA, Ajekigbe AT. Clinicopathological study of malignant gastric tumours in Lagos. Nig Q J Hosp Med. 2010;20:49-54.

Oluwasola AO, Ogunbiyi JO. Gastric cancers: Aetiological, clinicopathological and management patterns in Nigeria. Niger J Med. 2003;12:177-86.

Abdulkareem FB, Faduyile FA, Daramola AO, Rotimi O, Banjo AA, Elesha SO, et al. Malignant gastrointestinal tumours in south western Nigeria: A histopathologic analysis of 713 cases. West Afr J Med. 2009;28:173-6.

Jernal A, Siegel R, Ward E, Haoy, XUJ murray J, et al. can statites, 2008. CA cancer clinico. 2008;58:71-96.

Bakari AA, Ibrahim AG, Gali BM, Dogo D, Ngadda HA. Pattern of gastric cancer in north-eastern Nigeria: A clinicopathologic study. J Chin Clin Med. 2010;5:211-5.

Lazăr D, Tăban S, Sporea I, Dema A, Cornianu M, Lazăr E, et al. Gastric cancer: correlation between clinicopathological factors and survival of patients (II). Roma J Morpho Embryo. 2009;50(2):185-94.

Naoko T, Shingo I, Yasuko U, Masatoshi K. Mixed intestinal- and diffuse-type histology is a risk factor for lymph node metastasis submucosal invasive gastric cancer.Dig Endoscopy. 2008;20(1):17-21.

Ebili HO, Oluwasola AO, Akang EEU, Ogunbiyi JO. Clinicopathological features of gastric carcinoma in Ibadan, Nigeria, 2000-2011. Niger Med J. 2015;56(2):126-31.

Ahmed A, Ukwenya AY, Makama JG, Mohammad I. Management and outcome of gastric carcinoma in Zaria, Nigeria. Afr Health Sci. 2011;11:353-61.

Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Miwa S, et al. Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: An immunostaining study on the tissue microarray. J Clin Pathol. 2007;60:273-7.

Abdi-Rad A, Ghaderi-sohi S, Nadami-Barfroosh H, Emami S. Trends in incidence of gastric adenocarcinoma by tumour location from 1969-2004: A study in one referral centre in Iran. Diagn Pathol. 2006;1:5.

Lee HJ, Yang HK, Ahn YO. Gastric cancer in Korea. Gastric cancer. 2002;5(3):177-82.

Wang Z, Liu L, Ji J, Zhang J, Yan M, Zhang J, et al. ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta-Analysis. Int J Mol Sci. 2012;13(10):13308-21.