Coagulopathy in dengue fever patients

Abhilash Kannan, Kala Syamalakumari Narayanan, Sheetal Sasikumar, Jobin Philipose, Sreerag Alumparambil Surendran


Background:The study was done to find out the prevalence of coagulopathy in Dengue fever patients with thrombocytopenia and its clinical significance.

Methods:The patients admitted in medical wards and ICU were included in the study after considering certain inclusion and exclusion criteria. APTT, PT & D-dimer assays were also done in the study population. Coagulopathy was considered when APTT values were ≥41seconds.

Results:22.3% of the study population showed evidence of coagulopathy. Bleeding manifestations significantly increased with increasing APTT values. There is also significant association between platelet counts and bleeding manifestations. As platelet count falls there is a tendency for APTT to rise.

Conclusion:In addition to thrombocytopenia, coagulopathy also contribute to the presence of bleeding manifestations in dengue fever patients. There is a significant correlation between bleeding manifestations with abnormal APTT values. As platelet count decreases there is tendency for rise in APTT values.


Dengue fever, Thrombocytopenia, Coagulopathy, Bleeding manifestations

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World Health Organisation. Dengue guidelines for diagnosis, treatment, prevention and control. In: WHO, eds. WHO Guideline. Geneva: World Health Organisation; 2009: 1-147.

Huang YH, Liu CC, Wang ST, Lei HY, Liu HL, Lin YS, et al. Activation of coagulation and fibrinolysis during dengue virus infection. J Med Virol. 2001;63:247-51.

Andhika Rachman, Ikhwan Rinaldi. Coagulopathy in dengue infection and the role of interleukin-6. Acta Med Indones-Indones J Inter Med. 2006;38(2):106-8.