Quality of life among lung cancer patients undergoing treatment at a tertiary cancer institute in North India

Vijay Kumar Barwal, Salig Ram Mazta, Anita Thakur, Rajeev Kumar Seam, Manish Gupta


Background: Lung cancer patients mostly present with advanced disease. Its treatment has shown limited progress in recent decades, so we studied their quality of life (QOL) and how it is affected during treatment.

Methods: Patients ≥18 years of age, diagnosed/registered at our institute from 1st September 2012 through August 2013 were included in the study. QOL was assessed by means of the EORTC QLQ-C30 and QLQ-LC13. Data was analyzed using descriptive and inferential statistics

Results: Out of 91 patients included in the study, 73 (80.2%) were males and 18 (19.8%) were females. Mean age of the study population was 59.24±10.53 years and median age was 60 years. A better QOL for nausea and vomiting (P=0.011), sleep disturbance (p=0.021), and coughing (p=0.016) was observed in female patients. There was significant worsening in symptom scales of fatigue (p=0.000), nausea and vomiting (p=0.000), sleep (0.006), appetite (p=0.000) and constipation (p=0.000). Though the mean scores of pain, dyspnoea and financial difficulties decreased, but they were not significant. According to the LC13 module, significant improvement was seen in the symptom scales of cough (p=0.000), haemoptysis (p=0.000) and pain chest (p=0.040).

Conclusions: Lung cancer patients undergoing treatment suffer many limitations due to an array of symptoms and disruptions in various areas of QOL, arising from both the disease process and its treatment. It should be studied at every visit for each individual patient.


Measurements time points, Lung cancer, Treatment, Quality of life assessment

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Khurana S. Lung cancer fact sheet. South Asia network for chronic diseases. Pg10.

Urdaniz JI, Aguillo MM, Burgaleta AM, Pascual ES, López EM, García RV, et al. Quality of life assessment in Spanish lung cancer patients by the EORTC questionnaires. Oncología. 2005;28:174-82.

Carlsen K, Bonde JA, Jacobsen E, Krasnik M, Johansen C. Psychosocial aspects of lung cancer. Lung Cancer. 2005;47:293-300.

Maliski SL, Sarna L, Evangelista L, Padilla G. The aftermath of lung cancer: balancing the good and bad. Cancer Nurs. 2003;26:237-44.

Sanders SL, Bantum EO, Owen JE, Thornton AA, Stanton AL. Supportive care needs in patients with lung cancer. Psycho-Oncology. 2010;19:480-89.

Lung cancer and quality of life. Available from URL: . Accessed on 23rd October 2015.

Anant M, Guleria R, Pathak AK, Bhutani M, Pal H, Charu M et al. Quality of Life measures in lung cancer. Ind J Can. 2005;42:125-32.

Chen ML, Yu CT, Yang CH. Sleep disturbances and quality of life in lung cancer patients undergoing chemotherapy. Lung Cancer. 2008;62:391-400.

Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365-76.

Montazeri A, Gillis CR, McEwen J. Quality of Life in Patients With Lung Cancer: A Review of Literature From 1970 to 1995. Chest. 1998;113:467-81.

Svobodnik A, Yang P, Novotny PJ, Bass E, Garces YI, Jett JR, et al. Quality of Life in 650 Lung Cancer Survivors 6 Months to 4 Years After Diagnosis. Mayo Clin Proc. 2004;79:1024-30.

Mohan A, Mohan C, Bhutani M, Pathak AK, Pal H, Das C, et al. Quality of life in newly diagnosed patients with lung cancer in a developing country: is it important? Eur J Can Care. 2006;15:293-8.

Akin S, Can G, Aydiner A, Ozdilli K, Durna Z. Quality of life, symptom experience and distress of lung cancer patients undergoing chemotherapy. Eur J Oncol Nurs. 2010;30:1-10.

Sarna L. Women with lung cancer: impact on quality of life. Qual Life Res. 1993;2:13-22.

Smith EL, Hann DM , Ahles TA, Furstenberg CT, Mitchell TA, Meyer L, et al. Dyspnoea, anxiety, body consciousness, and quality of life in patients with lung cancer. Journal of pain and symptom management. 2001;21:323-9.

Güner P, Isikhan V, Kömürcü S, Oztürk B, Arpaci F, Ozet A. Quality of life and sociodemographic characteristics of patients with cancer in Turkey. Oncol Nurs Forum. 2006;33:1171-6.

Montazeri A, Hole DJ, Milroy R, McEwen J, Gillis CR. Quality of life in lung cancer patients: does socioeconomic status matter? Health and Quality of Life Outcomes. 2003;1:19.

Bergman B, Sullivan M, Renson S. Quality of life during chemotherapy for small cell lung cancer a longitudinal study of the EORTC core quality of life questionnaire and comparison with the sickness impact profile. Acta Oncol. 1992;31:19-28.

Montazeri A, Milroy R, Gillis C R, McEwen J. Quality of life: perception of lung cancer patients. European journal of cancer. 1996;32:2284-89.

Langendijk JA, Aaronson NK, de Jong JMA, ten Velde GPM, Muller MJ, Lamers RJ et al. Prospective Study on Quality of Life Before and After Radical Radiotherapy in Non–Small-Cell Lung Cancer. J Clin Oncol. 2001;19:2123-33.

Arraras JI, Martínez Aguillo M, Manterola Burgaleta A, Salgado Pascual E. Quality of life assessment in Spanish lung cancer patients by the EORTC questionnaires. Arch Esp Urol. 2008;61:949-54.

Mohan A, Singh P, Kumar S, Mohan C, Pathak AK, Pandey RM, et al. Effect of change in symptoms, respiratory status, nutritional profile and quality of life on response to treatment for advanced non-small cell lung cancer. Asian Pac J Cancer Prev. 2008;9:557-62.

Auchter RM, Scholtens D, Adak S, Wagner H, Cella DF, Mehta MP. Clinical investigation: lung. International Journal of Radiation Oncology*Biology*Physics. 2001;50:1199-206.

Maric D, Jovanovic D, Golubicic I, Dimic S, Pekmezovic T. Health-related quality of life in lung cancer patients in Serbia: correlation with socio-economic and clinical parameters. European Journal of Cancer Care 2009.

Jiancun CA, Wang Y, Zhang L, Ma L. Investigation of the Change of Quality of Life and Depression in Lung Cancer Patients before and after Chemotherapy. Chin J Lung Cancer. 2011;14:358-61.

Bircan A, Berktas MB, Bayz H, Baflay, Bircan S, Berkoglu M. Effects of Chemotherapy on Quality of Life for Patients with Lung Cancer. Turk Resp J. 2003;4:61-6.

Wintner LM, Giesinger JM, Zabernigg A, Sztankay M, Meraner V, Pall G, et al. Quality of life during chemotherapy in lung cancer patients: results across different treatment lines. Bri J Can. 2013;109:2301-8.

Li TC, Li CI, Tseng CH, Lin KS, Yang SY, Chen CY, et al. Quality of life predicts survival in patients with non-small cell lung cancer. BMC Public Health. 2012;12:790.