Comparative study of serum lipid profile between prehypertensive and normotensive

Hitesh A. Jani, Priti C. Bhanderi, Chandankumar Sharma, Maulik Padalia


Background: Prehypertensive subjects have greater risk of developing hypertension than the normotensive subjects. Studies have shown that lipid profile is altered in hypertensive patients as compare to normotensive subjects. But not much is documented about lipid profile in prehypertensives. So the present study is done to compare the serum lipid profile among prehypertensive and normotensives and to correlate the blood pressure and lipid profile in prehypertensives.

Methods: 50 prehypertensive and 50 normotensive subjects were recruited from the general population. Blood pressures were recorded and serum lipid profiles were measured and compare using student t test. Correlation of serum lipid profile and blood pressure was done using person correlation.

Results: The study results showed significant increased in total cholesterol, LDL, VLDL and serum triglyceride level in prehypertensives compare to normotensives. While there is no significant change in HDL level in prehypertensive compare to normotensive. And there is also a significant correlation between blood pressure and lipid profile in prehypertensive subjects.

Conclusion: Lipid profile is altered in prehypertensives compare to normotensives. That’s why timely diagnoses and life style modification is required in prehypertensives.



Blood pressure, Lipid profile, Prehypertension

Full Text:



The world health report 1999: the double burden emerging epidemics and persistent problems. Geneva, WHO;1999. Available from:, access on august 2013.

Gaffar A, Reddy KS, Singhi M. Burden of noncommunicable diseases in south asia. BJM 2004;328:807-10.

Kearney PM, Whelton M, Reynold K, Muntner P, Whelton PK, He J. global burden of hypertension: analysis of world wide data, Lancet 2005;365:217-23.

World hypertension league year book 2000-2001: fighting hypertension into next millennium. Toledo, OH: world hypertension league;2001. p.3-6.

Miller ER 3rd, Jehn ML. New high blood pressure guidelines create new at risk classification: change in blood pressure classification JNC 7. Cardiovascular. 2004;19(6):367-71.

Greenlund KJ, Croft JB, Mernsah GA. Prevalence of heart disease and stroke risk factors in person with prehypertension in united states, 1999-2000. Arch Intern Med 2004;164:2113-8.

Lizka HA, Mainous AG 3rd, King DE, Everett CJ, Egan BM prehypertension and cardiovascular morbidity. Ann Fam Med 2005;3:294-9.

Lili J. Diabetic dyslipidemia. Medicine update. 2000; 10:547.

Giles TD. Assessment of global risk : a foundation for new, better definition of hypertension. J clin hypertens (Greenwich). 2006;8(8):5-14.

Sathiyapriya V, Selvaraj N, Nandeesh H, Bobby Z, Aparna A, Pavtharn P. Association between protein bound sialic acid and high sensitivity C-reative protein in prehypertension: a possible indication of underlying cardiovascular risk. Clin Exp hypertens. 2008;30(5):367-74.

Nan EH, Kim HC. Comparison of cardiovascular risk factors between normotension and prehypertension. Korean J Lab Med. 2007; 27(5): 377-81.

Choi KM, Park HS, Han JH, Lee JS, Lee J, Ryu OH, Lee KW, Cho KH, Yoo D, Baisk SH, Choi DS, Kim SM: Prevalence of prehypertension and hypertension in a Korean population; Korean national health and nutrition survey 2001. J hypertens 2006,24:1515-1521.

Julius S, Nesbitt SD, Egan BM, Weber MA, Michenson EL, Kaciroti N, Black HR, Grimm RH Jr, Messerli FH, Oparil S, Schork MA: feasibility of treating prehypertension with an angiotensin receptor blocker. N engl J Med 2006,354:1685-97.