A case report on development of CNS primitive neuroectodermal tumour from astrocytoma

Sunnia Gupta, Narendra Rathore

Abstract


CNS PNET are infrequent in children and very rare in adults. Even rarer is the development of PNET from low grade astrocytoma. We hereby report a case of PNET arising from astrocytoma. Some similar cases have been reported in the past in which radiation was considered to be the etiological factor in the development of PNET from glial neoplasms but in this case the duration of conversion does not go in favour of radiation as the cause.


Keywords


PNET, Astrocytoma, k-Ras, Radiation therapy

Full Text:

PDF

References


Salvati M, Frati A, Russo N. Radiation-induced gliomas: report of 10 cases and review of the literature. Surg Neurol. 2003;60:60-7.

Robison LL, Bhatia S. Late-effects among survivors of leukaemia and lymphoma during childhood and adolescence. Br J Haematol. 2003;122:345-59.

Brustle O, Ohgaki H, Schmitt HP. Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene. Cancer. 1992;69:2385-92.

Dorfmuller G, Wurtz FG, Kleinert R, Lanner G. Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma. Acta Neurochir (Wien). 1997;139:749-55.

Hader WJ, Drovini-Zis K, Maguire JA. Primitive neuroectodermal tumors in the central nervous system following cranial irradiation: a report of four cases. Cancer. 2003;97:1072-6.