Ascites in CML: a rare extramedullary manifestation

Y. V. Bansod, Sandeep V. Kharkar, Arshish Raut, Piyush Choudalwar

Abstract


Ascites in chronic myeloid leukemia (CML) as an extramedullary manifestation is rarely reported in the literature. A young 23 year old female of chronic myeloid leukemia presenting with extramedullary disease as massive ascites. All stages of granulocytes and a few blasts similar to peripheral blood smear was present in ascitic fluid. Based on clinical symptoms and signs, bone marrow examination, ascitic fluid cytology and ultrasonography of abdomen she was diagnosed as a case of Chronic myeloid leukemia in chronic phase with extramedullary disease as massive ascites. After starting treatment with Imatinib mesylate favourable response was observed.


Keywords


Ascites, Chronic myeloid leukemia, Extramedullary, Imatinib mesylate

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References


E.L. Morris and J.P. Dutcher (2005). Blastic Phase of Chronic Myelogenous Leukaemia. Clinical Advances in Haematology & Oncology Volume 3.

Naito K, Mori T, Miyazaki K, Tsukada Y, Ikeda Y, Okamoto S (2003). Successful treatment of extramedullary blast crisis of chronic myelogenous leukemia with imatinib mesylate (STI571). Intern Med.42(8):740-2.

K. Kaushansky, M. Lichtman , E. Beutler, T. Kipps, J. Prchal , U. Seligsohn (2010) Williams Hematology, Eighth Edition, edited by K. Kaushansky, E. Beutler, U. Seligsohn (The McGraw-Hill Companies, Inc).

U. Das, V. K. Gupta, T. Nyandak, P.Yadav, SC Sharma,D. Srivastava, M.Kaushal.(2010) Pleural Involvement in Chronic Myelocytic Leukaemia –an Extra-medullary Blast Crisis. JIACM 11(4): 326-9.

H. W. Kim, S. S. Lee,M.H. Ryu, J. L. Lee,H. M. Chang,T.W. Kim,H.S. Chi*, W. K. Kim,J.S.Lee, Y.K. Kang(2006). A Case of Leukemic Pleural Infiltration in Atypical Chronic Myeloid Leukemia. J Korean Med Sci; 21: 936-9.

Sacchi S, Temperani P, Selleri L, Zucchini P, Morselli S, Vecchi A,Longo R, Torelli G, Emilia G, Torelli U(1990). Extramedullary pleural blast crisis in chronic myelogenous leukemia: cytogenetic and molecular study. Acta Haematol; 83: 198-202.

Aleem A, Siddiqui N(2005). Chronic myeloid leukemia presenting with extramedullary disease as massive ascites responding to imatinib mesylate. Leuk Lymphoma.46(7):1097-9.

S Sobolewski, N Sreeharan, and S M Rajah (1979). Successful management of cardiac tamponade in two cases of leukaemia. Br Med J. November 10; 2(6199): 1190.

D.Hammouda, M.Shaheen, R.Nassar(2011). Imatinib (Gleevec) Induced Worsening of Pericardial Effusion in CML. Fırat Tıp Dergisi; 16(2): 100-1.

Sokal JE et al, Blood 1984; 63: 789-99.

Hasford J et al, JNTL Cancer Inst 1998; 90: 850-8.