Hairy cell leukemia: a rare case report

Jyoti P. Sapre, Hetal J. Joshi, Menka H. Shah, Ronak D. Shah


Hairy cell leukemia (HCL) is a rare chronic B-cell leukemia accounting for 2% of all the leukemias and occurs more frequently in the elderly males. The etiology is unknown but possible relationships to radiation exposure, exposure to benzene, to farm animals and to commercial herbicides and pesticides have been identified. Familial predisposition among first degree relatives has been noted. It is characterized by distinctive cytoplasmic “hair like” projections on the cell surface of lymphoid cells, pancytopenia and splenomegaly. We report a rare case of 29 year old female, farm labourer presenting with fever, fatigue and weakness for 1 month. On examination the patient had hepatomegaly, massive splenomegaly and inguinal lymphadenopathy. After peripheral smear examination diagnosis of HCL was made which was confirmed by bone marrow aspiration examination, bone marrow biopsy and immunohistochemistry (IHC).


Hairy cell leukemia, Pancytopenia, Splenomegaly, Immunohistochemistry

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Wintrobe’s Clinical Haematology, 12th edition, 2009, 2257-2275.

Henry”s Clinical Diagnosis and Management by Laboratory Methods, 22nd edition, 2011, 636-637.

Barbara J. Bain, David M. Clark, Irvin A. Lampert, Bridget S. Wilkins. Bone Marrow Pathology, 4th edition, 322-326.

Hoffman: Hematology: Basic Principles and Practice, 6th edition, 2009, 246-248.

Frank Firkin, Colin Chesterman, David Penington, Bryan Rush. deGruchy’s Clinical Haematology in Medical Practice, 5th edition, 2005, 271-272.

Kumar: Robbins and Cotran Pathologic Basis of Disease, 8th edition, 614-615.

WHO Pathology and Genetics of tumours of haematopoietic and lymphoid tissue, 138-142.