Published: 2017-03-28

Dapsone hypersensitivity syndrome-rare complication of dapsone therapy

Muzaffar Maqbool, Fayaz A. Wani, Rakesh K. Koul, Parvaiz A. Shah


Among several other adverse effects of dapsone therapy, dapsone hypersensitivity syndrome is extremely rare but most life-threatening complication. Here we report a case of severe dapsone hypersensitivity syndrome in a 27-year-old female student diagnosed as immune thrombocytopenic purpura on dapsone therapy who was admitted with remittent fever, lymphadenopathy and skin rash and was managed successfully with drug withdrawal and systemic glucocorticoid therapy. The idea of reporting this case is to recognise the rare potentially life threatening adverse effect of dapsone therapy, its timely diagnosis and favourable outcome with systemic glucocorticoid therapy.


Dapsone, Hypersensitivity, Immune thrombocytopenic purpura, Lymphadenopathy, Skin rash

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