Betatrophin is correlated with glucagon and insulin release rather than insulin resistance marker in type 2 diabetes mellitus Iraqi women

Authors

  • Athir K. Mohammed Department of Biology, College of Sciences, University of Baghdad, AL-Jaderyia Campus, Baghdad
  • Faris A. K. Khazaal Obesity Research and Therapy Unit, Alkindy College of Medicine, University of Baghdad

DOI:

https://doi.org/10.18203/2320-6012.ijrms20163119

Keywords:

Betatrophin, Glucagon, Type 2 diabetes, HOMA-β, Homeostasis model assessment insulin resistance (HOMA-‎IR), Uric acid

Abstract

Background: Betatrophin mainly expressed in liver and adipose tissue, stimulates pancreatic β-cell proliferation in insulin resistance state and improves metabolic process‎ regulation. This study aimed to understand effective roles of betatrophin in diabetic and non-diabetic Iraqi women. Also, it’s correlation with some insulin markers, metabolic parameters and glucagon.

Methods: Eighty women participated in this cross-sectional study, (mean body mass index: 21 - 49 kg/m2; mean age: 25-50 years) were enrolled and classified according to the presence of diabetes into 2 groups (40 diabetic and 40 non-diabetic). Anthropometric, biochemical and metabolic parameters measured.

Results: Betatrophin level had no statistically significant differences between non-diabetics and diabetics. Serum betatrophin levels had no statistically significant positive or negative correlations with age, anthropometric, lipid profile, diabetic parameters, thyroid stimulating hormone, glucagon, irisin, glucagon like peptide -1 and hepatocyte growth factor except uric acid (r=0.2539, P =0.0231). Serum betatrophin had no statistically significant correlations with all variables in non-diabetic and diabetic groups except with homoeostasis model assessment- for β-cell function (HOMA-β) and glucagon (r=0.3647, P=0.0207; r=0.3403, P=0.0317 respectively) in the diabetic group. Stepwise regression showed that only uric acid was independently related factors to circulating betatrophin β=‎0.8500, P=0.02.

Conclusions: Betatrophin was positively correlated with HOMA-β and glucagon in type 2 diabetes mellitus women. Uric acid was a direct independent predictor of betatrophin level.

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Published

2016-12-19

How to Cite

Mohammed, A. K., & Khazaal, F. A. K. (2016). Betatrophin is correlated with glucagon and insulin release rather than insulin resistance marker in type 2 diabetes mellitus Iraqi women. International Journal of Research in Medical Sciences, 4(10), 4264–4271. https://doi.org/10.18203/2320-6012.ijrms20163119

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Original Research Articles