Superior vena cava obstruction as manifestation of synovial cell sarcoma: a case report and review of literature

Authors

  • Pravesh Dhiman Department of Medical Oncology, Imperial Cancer Hospital, Bangalore, Karnataka, India
  • C. N. Patil Department of Medical Oncology, Imperial Cancer Hospital, Bangalore, Karnataka, India
  • Renu Raghupathi Department of Medical Oncology, Imperial Cancer Hospital, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20171298

Keywords:

Chemotherapy, Mediastinum, Superior vena cava, Synovial cell sarcoma

Abstract

Synovial cell sarcomas are one of the most common soft tissue tumors affecting adolescents and young adults. The common location of these tumors is often extremities. Primary involvement of mediastinum is a very rare presentation of this tumor, only few cases have been reported so far. We are reporting the case of a 27-year-old male patient who presented to us with a history of dyspnoea and chest discomfort of one week duration along with features of SVC obstruction. Chest is a frequently involved site of metastasis and lymphomas but rarely involved in synovial sarcoma. The learning point from this case is that rare causes like synovial sarcoma of mediastinum should always be included in differential diagnosis of mediastinal mass and SVC obstruction. We are reporting this case in view of its rarity.  Though uncommon this case report emphasizes that synovial cell sarcoma should also be considered in differential diagnosis of mediastinal mass and early recognition with HPE, IHC and prompt institution of treatment can be lifesaving.

References

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Landstein R, Treunar J, Koscelniak E. Synovial sarcoma of childhood and adolescence. Cancer. 1993;71(11):3647-55.

Suster S, Moran CA. Primary synovial sarcoma of the mediastinum: A clinicopathologic, immunohistochemical and ultrastructural study of 15 cases. Am J Surg Pathol. 2005;29:569-78 .

Van GM, Van Oosterom AT, Oosterhius JW. Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: An analysis of 2,185 patients treated with anthracycline containing first line regimens- a European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol. 1999;17:10-157.

Kampe CE, Rosen G, Eilber F. Synovial Sarcoma. A study of intensive chemotherapy in 14 patients with localized disease. Cancer. 1993;72:2161-9.

Jeganath R, Davis R, Wilson L. Primary mediastinal Synovial sarcoma. Ulster Med J. 2007;76:109-11.

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Published

2017-03-28

How to Cite

Dhiman, P., Patil, C. N., & Raghupathi, R. (2017). Superior vena cava obstruction as manifestation of synovial cell sarcoma: a case report and review of literature. International Journal of Research in Medical Sciences, 5(4), 1721–1723. https://doi.org/10.18203/2320-6012.ijrms20171298

Issue

Section

Case Reports