Effectiveness of oral itraconazole in the management of otomycosis with tympanic membrane perforation
Keywords:Itraconazole, Otomycosis, Tympanic membrane perforation
Background: Otomycosis can be a difficult problem to treat in a patient who already has a perforation of the tympanic membrane. This study highlights the effectiveness of oral Itraconazole in treating such cases.
Methods: Thirty-four patients with otomycosis and a perforated tympanic membrane were included in the study and were treated with oral itraconazole and antibiotic ear drops. They were followed up for six weeks to look for treatment response and any recurrence.
Results: Of the 34 patients in the study, 25 patients were fully cured with one week of oral Itraconazole therapy. Six out of the remaining 9 patients were cured of the disease with two weeks’ therapy. Three patients needed prolonged treatment and one patient had a recurrence at six weeks.
Conclusions: Oral itraconazole therapy is an effective alternative to the traditional methods of treatment for otomycosis with tympanic membrane perforation.
Jackman A, Ward R, April M, Bent J. Topical antibiotic induced otomycosis. Int J Pediatr Otorhinolaryngol. 2005;69(6):857-60.
Anwar K, Gohar MS. Otomycosis; clinical features, predisposing factors and treatment implications. Pak J Med Sci. 2014;30:564-7.
Kumar A. Fungal Spectrum in Otomycosis Patients. JK science. 2000;7(3):152-5.
Arndal E, Glad H, Homoe P. Large discrepancies in otomycosis treatment in private ear, nose and throat clinics in Denmark. Danish Med J. 2016;63(5):A5231.
Hurst WB. Outcome of 22 cases of perforated tympanic membrane caused by otomycosis. J Laryngol otol. 2001;115:870-80.
Munguia R, Daniel SJ. Ototopical antifungals and otomycosis: A review. International journal of pediatric otorhinolaryngology. 2008;72;4:453-9.
Kurnatowski P, Filipiak J. Otitis externa: the analysis of relationship between particular signs/symptoms and species and genera of identified microorganism. Wiad Parazytol. 2008;54:37-41.
Venkataraman R, Kumar RS. Efficiency of 5 Day Course Oral Itraconazole in Management of Recurrent Otomycosis in Diabetic Patients- a Randomized Control Clinical Trail. Paripex - IndianJournal of research. 2016;15(1):96-8.
Vennewald I, Klemm E. Otomycosis: Diagnosis and treatment. Clinics in Dermatology. 2010;28(2):202-11.
Gupta AK, Chwetzoff E, Del Rosso J, Baran R. Hepatic safety of Itraconazole. J Cutan Med Surg. 2002;6(3):210-3.
Amesara R, Suzumara E, Ryuichiro, SetsuoNakamoto. Effect of Oral Itraconazole Tablets on Otomycosis. Practica Oto-Rhino-Laryngologica. 1999;92(2):201-6.