Role of conventional oral antidiabetic drugs in management of type 2 diabetes mellitus


  • Vaishali Thakare Assistant Professor, Department of Pharmacology, D. Y. Patil University School of Medicine, Nerul, Navi Mumbai, Maharashtra, India
  • Shrikrishna S. Shende Junior Resident, Department of Pharmacology, D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India
  • Prashant A. Shirure Department of Pharmacology, Dr. V. M. Medical College, Solapur, Maharashtra, India
  • Onkar C. Swami Head - Medical Services, Unichem Laboratories Ltd, Jogeshwari (West), Mumbai, Maharashtra, India



India, Oral antidiabetic drugs, T2DM


Type 2 diabetes mellitus (T2DM) is caused by insulin resistance and characterized by progressive pancreatic β-cell dysfunction. Recent innovative treatment approaches target the multiple pathophysiological defects present in type 2 diabetes. The targets for glycemic control as set by the American Diabetes Association (HbA1C<7%) and the American Association of Clinical Endocrinologists (HbA1C<6.5%) sometimes appear daunting and unattainable. It is therefore of the utmost importance to have an excellent understanding of the mechanism of action of these drugs in order to optimize patient therapy. Here, we present a corresponding discussion of all the available oral antidiabetic drugs according to the different classes, their mechanisms of action and pharmacological profiles.


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How to Cite

Thakare, V., Shende, S. S., Shirure, P. A., & Swami, O. C. (2017). Role of conventional oral antidiabetic drugs in management of type 2 diabetes mellitus. International Journal of Research in Medical Sciences, 5(3), 749–758.



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