Published: 2017-04-26

Kikuchi Fujimoto lymphadenitis- an uncommon entity in the surgical outpatients: a case report

Anuradha Panchal, Raj Gautam, Abhishek Mahadik, Qurratulain Chougle, Mohammed Zeba Shaffi


Kikuchi Fujimoto lymphadenitis is a benign self-limiting disease with subacute necrotizing lymphadenopathy of unknown cause. The clinical, histopathological and immunohistochemical features point to viral etiology hence delaying diagnosis commonly. Clinicians and pathologists awareness of this disorder may prevent misdiagnosis and inappropriate treatment. We describe here a case of a young woman admitted under our care with fever and cervical lymphadenopathy. Cervical lymph node biopsy revealed the rare clinical disorder of Kikuchi Fujimoto lymphadenitis which is not thought of as a primary cause of lymphadenopathy in the Indian subcontinent where tuberculosis is widely prevalent.


Kikuchi Fujimoto, Necrotizing lymphadenitis

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Mohanty SK, Arora R, Saha M. Kikuchi Fujimoto disease: an overview. J Dermatol. 2002;29:10-4.

Lopez C, Oliver M, Olavarria R, Sarabia MA, Chopite M. Kikuchi Fujimoto necrotizing lymphadenitis associated with cutaneous lupus erythematosus: a case report. Am J Dermatophthal. 2000;22(4):328-33.

Norris AH, Krasinskas AM, Salhany KE, Gluckman SJ. Kikuchi Fujimoto disease: a benign cause of fever and lymphadenopathy. Am J Med. 1996;101(4):401-5.

Scheinfeld NS. Cutaneous Kikuchi disease. eMedicine Medscape. (Last accessed Feb 2009). Available from: http:// article/1124957-overview.

Qadri F, Atkin GK, Thomas D, Das S.K. Kikuchi’s disease: an important cause of cervical lymphadenopathy. Clin Med. 2007;7(1):82-4.

Dorfman RF, Berry GJ. Kikuchi’s histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol. 1988;5(4):329-45.

Imamura M, Ueno H, Matsuura A, Kamiya H, Suzuki T, Kikuchi K, et al. An ultrastructural study of subacute necrotizing lymphadenitis. Am J Pathol. 1982;107(3):292-9.

Mahadeva U, Allport T, Bain B, Chan WK. Haemophagocytic syndrome and histiocytic necrotising lymphadenitis (Kikuchi’s disease). J Clin Pathol. 2000;53:636-8.

Chen JS, Chang KC, Cheng CN, Tsai WH, Su IJ. Childhood hemophagocytic syndrome associated with Kikuchi’s disease. Hematologica. 2000;85:998-1000.

Chen YH, Lan JL. Kikuchi’s disease in systemic lupus erythematosus: clinical features and features and literature review. J Microbiol Immunol Infect. 1998;31:187-92.

Graham LE. Kikuchi-Fujimoto disease and peripheral arthritis: a first. Ann Rheum Dis. 2002;114:709-11.