Published: 2017-03-28

Adverse donor reaction during and after plateletpheresis in a tertiary care centre

Kajal Khajuria, Vijay Sawhney, Raman Sharma, Sonia Gupta


Background: Plateletpheresis is the process of collecting platelets, a component of blood involved in blood clotting. The term specifically refers to the method of collecting the platelets, which is performed by a device used in blood donation that separate the platelets and return other portion of blood to the donor. Platelet transfusion can be a life-saving procedure in preventing and treating serious complications from bleeding and haemorrhage in patients having disorders manifesting as thrombocytopenia like in dengue patients, ITP, aplastic anemia, and patients undergoing chemotherapy for leukaemia. In this study, our goal was to retrospectively analyse the adverse reactions occurred during and immediately after plateletpheresis donations.

Methods: From January 2015 to October 2016, a total of 66 plateletpheresis procedures were performed in department of transfusion medicine, GMC Jammu, Jammu and Kashmir, India which is a tertiary care hospital.

Results: Total 66 procedures were performed during our study period from which, four (6.06%) adverse events were recorded. Out of these four, two (50%) donors suffered from tingling sensation, one (25%) suffered from nausea and vomiting and One (25%) from haematoma formation.

Conclusions: In Conclusion, the result of our 22-month study survey document that apheresis procedures performed on cell separators are safe procedures with the low incidence of adverse reactions.


Adverse events, Plateletpheresis, Thrombocytopenia

Full Text:



Souza MH, Elias DO. Principios de Hematologia e Hemoterapia. 2005.

Dass SS, Choudhary RK, Shukla JS. Factors influencing yield of plateletpheresis using intermittent flow cell separator. clin lab Haematol. 2005;27:316-9.

Brasil. Agencia Nacional de vigilancia Sanitaria. RDC no. 57, de 16 de dezembro de. 2010. 2010.

Mcleod BC, Price TH, Owen H, Ciavarella D, Sniecinski I, Randels MJ et al. Frequency of immediate adverse effects associated with apheresis donation. Transfusion. 1998;38:938-43.

Brecher ME, Leger RM et al. AABB technical manual. 15th ed., Bethesda: American association of blood bank. 2005.

Tomita T, Takayanagi M, Kiwada K, Mieda A, Takahashi C, Hata T. Vasovagal reactions in apheresis donors. Transfusion. 2002;42:1561-6.

Despotis GJ, Goodnough LT, Dynis M, Baorto D, Spitznagel E et al. Adverse events in platelet apheresis donors: A multivariate analysis in hospital based program. Vox Sang. 1999;77:24-32.

Winters JL. Complication of donor apheresis. J clin. Apher et al. 2006;21:132-41.

Simon TL, Dzik WH. Rossi’s principles of transfusion medicine. 4th ed. Philadelphia: Lippincott Williams & Wilkins. 2009.

Klein HG, Anstee DJ. Mollison’s blood transfusion in clinical medicine. 11th ed. Bristol (UK): Blackwell Publishing Ltd. 2005.

Bolan CD, Greer SE, Cecco SA, Oblitus JM, Rehak NN, Leitman SF. Comprehensive analysis of citrate effects during plateletpheresis in normal donors. Transfusion. 2001;41:1165-71.

Bell AM, Nolen JF, Knudson CM. Severe citrate toxicity complicating volunteer apheresis platelet donation. J clinApher. 2007;22:15-6.

Crookes RL, Hillyer CD. Blood banking and transfusion medicine. 2nd ed. Philadelphia: Churchill Livingstone. 2009.

Philip J, Sarkas RS, Pathak A. Adverse events associated with apheresis procedures. Incidence and Relative freq. Asian J Transfusion. 2013;7:37-41.