A case control study of possible additional risk factors for chronic alcoholic pancreatitis

Authors

  • Sri Vengadesh Gopal Department of General Surgery, Indira Gandhi Medical College and Research Institute (IGMCRI), Pondicherry
  • Ashley Solomon Department of General Surgery, Indira Gandhi Medical College and Research Institute (IGMCRI), Pondicherry
  • Jaahnavi Konidala Department of General Surgery, Indira Gandhi Medical College and Research Institute (IGMCRI), Pondicherry

DOI:

https://doi.org/10.18203/2320-6012.ijrms20163296

Keywords:

Pancreatitis, Chronic, Alcoholic, Risk factors

Abstract

Background: Chronic pancreatitis (CP) is characterised by irreversible damage to pancreas leading to endocrine and exocrine insufficiency with considerable morbidity. Etiopathogenesis is multifactorial with interplay between genetics & environmental toxins. Alcoholism is more commonly associated with chronic pancreatitis. But it is not very clear why only certain proportion of the alcoholics develop pancreatitis. So this study was conducted to find the possible additional risk factors involved in alcoholic pancreatitis.

Methods: A total of 30 patients with alcoholic pancreatitis from a tertiary care hospital in Pondicherry, India were enrolled and compared with age matched alcoholics without pancreatitis. The diagnostic criteria for alcoholism were based on diagnostic and statistical manual of mental disorders (DSM) criteria IV of alcohol consumption >80gms/day for a period of 5 years or more and chronic pancreatitis was based on significant clinical findings and positive ultrasound findings of pancreatitis. Questions regarding additional risk factors of pancreatitis like smoking, blood group and Diabetes mellitus were asked and recorded using the standard questionnaire.

Results: Smoking history was noted in 73% of cases and 63.4% of controls. Non O blood group was noted in 56.6% of cases and 46.6% of controls. 10% of cases and 6.6% of controls gave history of diabetes before the development of pancreatitis. The additional risk factors were almost similar in both the groups and there was no statistical difference.

Conclusions: It was concluded that there is no statistically significant additional risk factors for chronic alcoholic pancreatitis noted in present study and a study with a large sample size for an extended period is recommended.

References

Garg PK, Tandon RK. Survey on chronic pancreatitis in the Asia–Pacific region. J Gastroenterol Hepatol. 2004;19:998-1004.

Balakrishnan V, Unnikrishnan AG, Thomas V, Choudhuri G, Veeraraju P, Singh SP, et.al. Chronic Pancreatitis. A Prospective Nationwide Study of 1,086 Subjects from India. J Pancreas. 2008;9(5):593-600.

Rajesh G, Balakrishnan V. Chronic pancreatitis: South Indian Perspective. Medicine Update. 2012;8(6):445-50.

Yadav D, Hawes RH, Brand RE, Anderson MA, Money ME, Banks PA, et al. Alcohol consumption, cigarette smoking and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med. 2009;169(11):1035-45.

Julia GB, Jessica R, Brand RF, O'Connell MR, Yadav D, Whitcomb DC. ABO Blood Group and Chronic Pancreatitis Risk in the NAPS2 Cohort. 2011;40(8):1188-94.

Noel R, Braun DK, Patterson RE, Bloomgren GI. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: A retrospective cohort study. Diabetes care. 2009;32(5):834-8.

Morton C, Klatsky AL, Udaltsova N. Smoking, coffee and pancreatitis. Am J Gastroenterol. 2004;99(4):731-8.

Lee AT, Xu Z, Pothula SP, Patel MB, Pirola RC, Wilson JS, et al. Alcohol and Cigarette Smoke Components Activate Human Pancreatic Stellate Cells: Implications for the Progression of Chronic Pancreatitis. Alcohol Clin Exp Res. 2015;39(11):2123-33.

Lin HH, Chang HY, Chiang YT, Wu MS, Lin JT, Liao WC. Smoking, drinking, and pancreatitis: a population-based cohort study in Taiwan. Pancreas. 2014;43(7):1117-22.

Maire F, Rebours V, Vullierme MP, Couvelard A, Lévy P, Hentic O, et al. Does tobacco influence the natural history of autoimmune pancreatitis? Pancreatology. 2014;14(4):284-8.

Rebours V, Vullierme MP, Hentic O, Maire F, Hammel P, Ruszniewski P, et al. Smoking and the course of recurrent acute and chronic alcoholic pancreatitis: a dose-dependent relationship. Pancreas. 2012;41(8):1219-24.

Weiss FU, Schurmann C, Guenther A, Ernst F, Teumer A, Mayerle J, et al. Fucosyl-transferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study. Gut. 2015;64(4):646-56.

Woo SM, Joo J, Lee WJ, Park S, Han S, Kim TH, Koh YH, et al. Risk of pancreatic cancer in relation to ABO blood group and hepatitis C virus infection in korea: A case control study. J Korean Med Sci. 2013;28:247-51.

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Published

2016-12-19

How to Cite

Gopal, S. V., Solomon, A., & Konidala, J. (2016). A case control study of possible additional risk factors for chronic alcoholic pancreatitis. International Journal of Research in Medical Sciences, 4(10), 4376–4379. https://doi.org/10.18203/2320-6012.ijrms20163296

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Original Research Articles