Published: 2017-04-26

Estimation of serum cortisol levels and its correlation with salivary cortisol levels in coronary artery disease patients with and without periodontitis: a cross sectional study

Ria Susan George, Nandini Manjunath, Manjunath B. V., Kishore Bhat


Background: Atherosclerosis refers to combination of changes in the intima of arteries, consisting of focal accumulation of lipids, complex carbohydrates, blood and blood products, fibrous tissue, calcium deposits and associated medical changes. Ischemic heart disease (IHD) refers to a group of closely related syndromes that is caused by an imbalance between myocardial oxygen demand and blood supply.

Methods: A cross-sectional study was conducted on 63 patients, aged 30-65 years, with known coronary artery disease. Estimation of serum and salivary cortisol levels were assessed with specific ELISA kit for cortisol (R&D Systems) and their comparison was performed in patients with and without periodontitis. Statistical analysis was done using Mann-Whitney U test and Pearson Correlation test.

Results: The clinical parameters showed statistically significant association (p<0.001) between coronary artery disease and periodontitis and comparative levels of serum and salivary cortisol displayed varying degrees of positive correlation.

Conclusions:Saliva along with serum has great potential as a diagnostic fluid and it showed good correlation with cortisol levels in coronary artery disease patients with and without periodontitis.



Coronary artery disease, HPA axis dysfunction, Periodontitis, Salivary cortisol, Serum cortisol

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