A cross sectional study evaluating the association of serum calcium, serum magnesium, and body mass index in premenopausal and postmenopausal women

Authors

  • Neelakkhi Kalita Department of Physiology, Gauhati Medical College, Guwahati, Assam, India
  • Biju Dutta Choudhury Department of Physiology, Gauhati Medical College, Guwahati, Assam, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20171824

Keywords:

Body mass index, Premenopausal women, Postmenopausal women, Serum calcium, Serum magnesium

Abstract

Background: To determine serum calcium, serum magnesium, and BMI (body mass index) in premenopausal and postmenopausal women, and find out any changes in these after menopause, and  the independent association of serum calcium, serum magnesium with BMI in pre and post-menopausal women , if any.

Methods: 100 adult women attending Gauhati medical college outdoor clinics were included in the study. Patients with medical history of major systemic diseases, women on hormone replacement therapy, and women who had surgical menopause were not included in the study. Estimation of serum calcium and serum magnesium from cubital venous blood was done by photocolorimetry method. For statistical analysis the value of laboratory parameters were presented as the Mean±SD (standard deviation). A Student’s unpaired t-test was used for cross-sectional comparisons of continuous variables between the groups.

Results: The mean serum calcium and also the mean serum magnesium levels were lower in the postmenopausal group and was statistically significant. Though the mean BMI in the postmenopausal group was higher than the premenopausal group, it was found to be statistically not significant.

Conclusions: The postmenopausal subjects had lower mean values of serum calcium and serum magnesium, but within the normal serum reference values.

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Author Biography

Neelakkhi Kalita, Department of Physiology, Gauhati Medical College, Guwahati, Assam, India

Post Graduate Trainee 

Department of Physiology

Gauhati Medical College, Guwahati, India

References

Sachdeva A, Seth S, Khosla AH, Sachdeva S. Study of some common biochemical bone turn over markers in post menopausal women. Indian J Biochemistry. 2005;20(1):131-4.

Pitkin RM, Reynolds WA. Williams GA, Hargis GK. Calcium regulating hormones during the menstrual cycle. J Clin Endocrinol Metabol. 1978:47:626-32.

Fujita T. Calcium paradox: consequences of calcium deficiency manifested by a wide variety of diseases. J Bone Miner Metab. 2000;18:234-6.

Anke M. Role of trace elements of in the dynamics of arteriosclerosis. Z Gesamte Inn Med. 1986;41(4):105-11.

Jandial S, Kaur G, Kumar S, Choudhary PR. Study of Serum Calcium and Magnesium Levels in Post Menopausal Women. The Indian J Nutrition and Dietetics. 2014;51(1):76-81.

Henry RP, Davies KM, Barger–Lux MJ. Calcium and weight clinical studies. J American College of Nutrition. 2002;21(2):152S-5S.

Kumar SKH. Bhaskar P. Osteoporosis an emerging disease of the 21st century. J Fam Med Prim Care. 2012:66-6.

Uebelhart D, Schlemmer A, Johansen JS, Gineyts E, Christiansen C, Delmas PD. Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links. J Clin Endocrinal Metab. 1991;72:367-73

Christiansen C, Delmas PD. Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links. J Clin Endocrinol Metab. 1991;72:367-73.

Bhale DV, Ansari HA. Study of serum calcium levels in postmenopausal women of Aurangabad district. International J Recent Trends in Science an Technology. 2014;9(3):332-3.

Indumati V, Patil VS, Jailkhan R. Hospital based preliminary study on osteoporosis in postmenopausal women. Indian J clinical Biochemistry. 2007;22(2):96-100.

Khatake PD, Jadhav SS, Afroz S. Relation between serum calcium level, bone mineral density and blood pressure in post menopausal women. International Journal of Recent Trends in Science and Technology.2013;7(3):86-8.

Qureshi HJ, Hussain G, Jafary ZA, Bashir MU, Latif N, Riaz Z. Calcium status in premenopausal and postmenopausal women. J Ayub Med Coll Abbottabad. 2010;22(2):143-5.

Gallagher JC, Kinyamu HK, Fowler SE, Dawson‐Hughes B, Dalsky GP, Sherman SS. Calciotropic hormones and bone markers in the elderly. Journal of Bone and Mineral Research. 1998;13(3):475-82.

Gupta N, Arora KS. Trace elements after menopause: A comparative study. J Clinical and Diagnostic Reserarch. 2011;5(4):795-7.

Hodgekinson A. Plasma electrolyte concentrations in women and the effect of estrogen administration. Maturitas. 1982;4:247-56.

Riggs BL, Arnaud CD, Jowsey J, Goldsmith RS, Kelly PJ. Parathyroid function in primary osteoporosis. Journal of Clinical Investigation. 1973;52(1):181.

Muneyyirci-Delale O, Nacharaju VL, Dalloul M, Altura BM, Altura BT. Serum ionized magnesium and calcium in women after menopause: inverse relation of estrogen with ionized magnesium. Fertility and sterility. 1999;71(5):869-72.

Heany RP, Recker RR, Sarille PD. Menopausal changes in calcium balance performance. J Lab Clin Med. 1978;92:953.

Ireland P, Fordtrans JS. Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion. J Clin Invest. 1973;52:2672.

Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, DeLuca HF. Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest. 1979;64(3):729-36.

Ilich JZ, Brownbill RA, Tamborini L. Bone and nutrition in elderly women: protein, energy, and calcium as main determinants of bone mineral density. Eu J of Clin Nutr. 2003;57:554-65.

Bhattarai T, Bhattacharya K, Chaudhuri P, Sengupta P. Correlation of common biochemical markers for bone turnover, serum calcium, and alkaline phosphatase in post-menopausal women. The Malaysian J Medical Sciences. 2014;21(1):58.

Jorde R, Sundsfjord J, Bønaa KH. Determinants of serum calcium in men and women. The Tromsø Study. Eur J Epidemiol. 2001;17(12):1117-23.

Saltman PD, Strause LG. The role of trace minerals in osteoporosis. J Am Nutr. 1993;12:384-9.

Grochans E, Karakiewicz B, Kozielec T, Brodowska A, Brodowski J, Starczewski A, et al. Serum Mg and Zn levels in postmenopausal women. Magnesium research. 2012;24(4):209-14.

McNair P, Christiansen C, Transbol I. Effect of menopause and estrogen substitutional therapy on magnesium metabolism. Miner Electrol Metab. 1984;10:84-7.

Lindsay R, Hart DM, Ferrest C. Effect of a natural and artificial menopause on serum, urinary and erythrocyte magnesium. Clin Sci. 1980;58:255-7.

Stanton MF, Lowenstein FW. Serum magnesium in women during pregnancy, while taking contraceptives, and after menopause. J Am Coll Nutr. 1987;6(4):313-9.

Mutlu M, Argun M, Kilic E, Saraymen R, Yazar S. Magnesium, zinc and copper status in osteoporotic, osteopenic and normal postmenopausal women. J International Medical Research. 2007;35:692-5.

Crawford SL, Casey VA, Avis NE, McKinlay SM. A longitudinal study of weight and the menopause transition: results from the Massachusetts Women's Health Study. Menopause. 2000;7(2):96-104.

Pasquali R, Casimirri LF, Labate AM, Tortelli O, Pascal G, Anconetani B, et al. Body weight, fat distribution and the menopausal status in women. Maturitas. 1995;3(21):259.

Pasquali R, Vicennati V, Bertazzo D, Casimirri F, Pascal G, Tortelli O, Labate AM. Determinants of sex hormone—binding globulin blood concentrations in premenopausal and postmenopausal women with different estrogen status. Metabolism. 1997;46(1):5-9.

den Tonkelaar I, Seidell JC, van Noord PA, Baanders-van Halewijn EA, Ouwehand IJ. Fat distribution in relation to age, degree of obesity, smoking habits, parity and estrogen use: a cross-sectional study in 11825 Dutch women participating in the DOM-project. Int J Obes. 1990;14:753-61.

Tonkelaar ID, Seidell JC, Van Noord PA, Baanders-van Halewijn EA, Jacobus JH, Bruning PF. Factors influencing waist/hip ratio in randomly selected pre-and post-menopausal women in the dom-project (preliminary results). International J obesity. 1988;13(6):817-24.

Ley CJ, Lees B, Stevenson JC. Sex- and menopause associated changes in body-fat distribution. Am J Clin Nutr. 1992;55:950-4

Song CH, Choi WS, Kim KS. Associations of serum minerals with body mass index in adult women. European J Clinical Nutrition. 2007;61:682-5.

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Published

2017-04-26

How to Cite

Kalita, N., & Choudhury, B. D. (2017). A cross sectional study evaluating the association of serum calcium, serum magnesium, and body mass index in premenopausal and postmenopausal women. International Journal of Research in Medical Sciences, 5(5), 1953–1958. https://doi.org/10.18203/2320-6012.ijrms20171824

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Original Research Articles