Bacteriological profile of acute bacterial meningitis at a tertiary care hospital of North India

Authors

  • Amresh Kumar Singh Department of Microbiology, BRD Medical College, Gorakhpur, Uttar Pradesh
  • Ankur Kumar Department of Microbiology, BRD Medical College, Gorakhpur, Uttar Pradesh
  • Vivek Gaur Department of Microbiology, BRD Medical College, Gorakhpur, Uttar Pradesh
  • Kusum Jasuja Department of Microbiology, BRD Medical College, Gorakhpur, Uttar Pradesh
  • Jayesh Pandey Department of Microbiology, BRD Medical College, Gorakhpur, Uttar Pradesh
  • Ruchi Mishra Department of Microbiology, BRD Medical College, Gorakhpur, Uttar Pradesh

DOI:

https://doi.org/10.18203/2320-6012.ijrms20163298

Keywords:

ABM, CSF, GPC, Sporadic or epidemic, Morbidity and mortality

Abstract

Background: Acute bacterial meningitis (ABM) is one of the most severe and potentially life-threatening infectious diseases. It is defined as an inflammation of the meanings, globally distributed as either sporadic or epidemic forms. ABM remains a major cause of mortality and long-term neurological sequel worldwide. Objective of the present study was undertaken to evaluate the bacteriological analysis in term of pathogens frequency and their sensitivity pattern in the cerebrospinal fluid of acute meningitis patients at a tertiary care hospital in eastern Uttar Pradesh, India.

Methods: The study was carried out at a tertiary care hospital from June 2014 to November 2015 irrespective of age group. A total of 3803 samples of cerebrospinal fluid (CSF) from clinically suspected cases of meningitis were subjected for bacteriological analysis.

Results: During the study period, a total of 3803 CSF samples were studied. Out of these, 343 were confirmed as bacterial meningitis based on Gram staining and or culture showing 9.01% incidence. ABM was more common in paediatric patients than adults. The most common organisms were Gram positive (66.18%) bacteria.

Conclusions: Acute bacterial meningitis is a medical emergency and making an early diagnosis and providing early and accurate treatment, are lifesaving and to reduce morbidity. This study may play an important role in the diagnosis and more accurate treatment for the ABM patients.

References

Gaurav MB, Komal PD, Sumeeta ST, Kanu PJ, Jayasukh MD, Pooja JS. Bacteriological profile of pyogenic meningitis in tertiary care hospital. National J Med Res. 2012;3(2):313-7.

Mani R, Pradhan S, Nagarathna S, Wasiulla R, Chandramuki A. Bacteriological profile of community acquired acute bacterial meningitis a ten-year retrospective study in a tertiary neurocare centre in south India. Indian J Med Microbiology. 2007;25(2):108-14.

WHO Expert Committee and WHO Statistics. 2011. Statistics about Meningitis. Prevalence and incidence statistics for meningococcal Meningitis Global health observatory data http://www.who.int/ gho/ epidemic_diseases/ meningitis/en/.

Annual report. 2014-15. Mortality/Morbidity Department of Neuromicrobiology NIMHANS Bangalore-560029 Karnataka India. http://www.nimhans.ac.in/ sites/ default/ files/ annual_ report/ NIMHANS% 20Annual% 20Report_2014-15_English_0.pdf

Park K. Text Book of preventive and social medicine. Banarsidas publications. Jabalpur. 2011;167-9.

Sudharshan RC, Reddy MP, Neelima A. Pattern and antibiogram of bacterial meningitis in children at a tertiary care hospital. J Scientific and Innovative Res. 2013;2(6):1012-6.

Bareja R, Pottathil S, Shah RK, Grover PS, Singh VA. Trends in bacterial etiology amongst cases of meningitis. J Acad Indus Res. 2013;1(12):761-5.

Collee JG, Fraser AG, Marmian BP. Mackie and McCartney Practical Medical Microbiology. Pearson Professional Ltd 14th edition. 1996. ISBN: 0443047219.

Ananthanarayan and Paniker. Text Book of Microbiology; Meningitis university press India 7th editions. 2014;667-9.

Clinical Laboratory Standard Institute. 2014. Performance standard for antimicrobial disk susceptibility tests. Approved standard-20th Ed. Supplement/ M2–A9 2006 26(1) microbiolab-bg.com/wp-content/uploads/2015/05/CLSI.pdf.

Khan F, Rizvi M, Fatima N, Shukla I, Malik A, Khatoon R. Bacterial meningitis in North India Trends over a period of eight years. Neurology Asia. 2011;16(1):47-56.

Centre for Disease Control and Prevention. MVPDB/ Meningitis Laboratory Atlanta Georgia 30329 USA; http://www.cdc.gov/ meningitis /bacterial.html.

Tang LM, Chen ST, Hsu WC, Lyu RK. Acute Bacterial Meningitis meningitis in adults a hospital based epidemiological study. QJM. 1999;92:719-25.

Modi S, Anand AK. Phenotypic Characterization and Antibiogram of CSF Isolates in Acute Bacterial Meningitis. J Clin Diagos Res. 2013;7(12):2704-8.

Yadhav KML. Study of Bacterial Meningitis in Children below 5 Years. Journal of Clinical and Diagnostic Research. 2014;8(4):DC04-6.

Basri R, Zueter AR, Mohamed Z, Alam MK, Norsa’adah B, Hasan SA, et al. Burden of bacterial meningitis a retrospective review on laboratory parameters and factors associated with death in meningitis Kelantan Malaysia. Nagoya J Medical Sci. 2015;77(1-2):59-68.

Liu CC, Chen JS, Lin CH, Chen YJ, Huang CC. Bacterial meningitis in infants and children in southern Taiwan Emphasis on Haemophilus influenzae type b infection. J Formos Med Assoc. 1993;92(10):884-8.

Chauhan D, Mokta K, Kanga A, Grover N, Singh D, Bhagra S. Group B streptococcal meningitis in children beyond the neonatal period in sub-Himalayan India. Annals of Indian Academy of Neurology. 2015;18(1):71-3.

Madhumita P, Gupta N. Clinical and Bacteriological spectrum of community acquired bacterial meningitis in adults at Tertiary Care Hospital in Northern India. Int J Nutr Pharmacol Neurol Dis. 2011;1194-200.

Tunkel AR, Hartman BJ, Kaplan SL. Practice Guidelines for the Management of Bacterial Meningitis. Clinical Infectious Diseases. 2004;39:1267-84.

Thomas K. Invasive Bacterial Infection Surveillance (IBIS) group International Clinical Epidemiology Network (INCLEN) Prospective multi centric hospital surveillance of Streptococcus pneumoniae disease in India. Lancet. 1999; 353:1216-21.

Shrestha RG, Tandukar S, Ansari S. Bacterial meningitis in children under 15 years of age in Nepal BMC Pediatrics. 2015;15:94.

Farag HFM, Fattah–Abdel MM, Youssri AM. Bacterial meningitis among children in Alexandria. Indian J Med Microbiol. 2005;23(2):95-101.

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Published

2016-12-19

How to Cite

Singh, A. K., Kumar, A., Gaur, V., Jasuja, K., Pandey, J., & Mishra, R. (2016). Bacteriological profile of acute bacterial meningitis at a tertiary care hospital of North India. International Journal of Research in Medical Sciences, 4(10), 4387–4393. https://doi.org/10.18203/2320-6012.ijrms20163298

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Original Research Articles