DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20163303

Fine needle aspiration cytology of breast lesions and correlation with histopathology

Ramesh S. Waghmare, Shubhangi D. Sakore, S. B. Rathod

Abstract


Background: Breast carcinoma is the leading cause of death due to cancer in women. It is difficult to determine whether a lump is benign or malignant from clinical assessment. Fine needle aspiration cytology (FNAC) is a convenient and rapid procedure. Hence the present study was carried out to correlate fine needle aspiration cytology and histopathology of breast lesions.

Methods: A study consisting of fine needle aspiration cytology (FNAC) 134 of breast lesions and their histopathological correlation was conducted at tertiary health center in rural area, over a period of three years. The diagnostic accuracy of this series was assessed and compared with data obtained from the Indian and international literature. Statistical analysis like sensitivity, specificity, positive predictive value, efficiency, and negative predictive value were carried out.

Results: The diagnostic accuracy of this series i.e. sensitivity 88.24%, specificity 100%, positive predictive value 100%, efficiency 95.52%, and negative predictive value 93.2% was compared with similar studies in literature.

Conclusions: FNAC is an effective modality for the diagnosis of breast lesions. It is a safe, simple, and cost effective outpatient procedure associated with negligible complications. It helps the clinicians for early diagnosis and specific management thus reducing morbidity and mortality.


Keywords


Breast lesions, Cytology, Histopathology, Fine needle aspiration cytology

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References


Bell DA, Hajdu SI, Urban JA, Gaston JP. Role of aspiration cytology in the diagnosis and management of mammary lesions in office practice. Cancer. 1983;51:1182-9.

Rocha PD, Nadkarni NS, Menezes S. Fine needle aspiration biopsy of breast lesion and histopathologic correlations, an analysis of 837 cases in four years. Acta cytol. 1997;41:1131-7.

Frable WJ. Needle aspiration of the breast, a personal experience with 469 cases. Cancer. 1984;53:671-6.

Sreenivas M, Kumar GH, Reddy SJ, Bhaskaran CS. Role of fine needle aspiration cytology in the diagnosis of breast lumps and its histopathological correlation. Ind J Pathol Microbial. 1989;32:133-7.

Kline TS, Joshi LP, Neal HS. Needle aspiration of the breast: diagnosis and pitfalls: A review of 3543 cases. Cancer. 1979;44:1458-64.

Bukhari MH, Arshad M, Jamal S, Niazi S, Bashir S, Bakhshi IM, et al. Use of fine- needle aspiration in the evaluation of breast lumps. Pathol Res Int. 2011;article ID 689521:1-10.

Hashemzadeh SH, Kumar PV, Malekpour N, Hashemi Z, Fatahi F, Malekpour F. Diagnostic accuracy of fine needle aspiration cytology: comparision of result in Tabriz Imam Khomoni Hospital and Shiraz University of medical sciences. Iran J Cancer Prev. 2009;2:133-6.

Pradhan M, Dhakal HP. Study of breast lump of 2246 cases by fine needle aspiration. J Nepal Med Assoc. 2008;47:205-9.

Shrestha A, Chalise S, Karki S, Shakya G. Fine needle aspiration cytology in a palpable breast lesion. J Pathol Nepal. 2011;1:131-5.

Zuk JA, Maudsley G, Zakhour H D. Rapid reporting on fine needle aspiration of breast lumps in outpatients. J Clin Pathol. 1989;42:906-11.

Bibbo M, Abati K. the uniform approach to breast fine needle aspiration biopsy. Acta cytol. 1996;40:1119.

Wang HH, Ducatman. Fine needle aspiration of breast. Acta cytol. 1998;42:285-9.

Gupta SK, Ghosh AK, Choudhary T, Dutta TK, Talwar BL, Dutta BN. Aspiration cytology in diagnosis of breast cancer. Indian J cancer. 1979;16:1-8.

Sheryl LW, Ibrahim R. analysis of false results in a series of 835 fine needle aspirates of breast lesions. Acta Cytol. 1995;39:858-9.

Palombini L, Fulcini F, Vetrani A. Fine needle aspiration biopsy in the diagnosis of breast masses. Cancer 1988;61:2273-7.

Kher AV, Marwar AW, Raichur BS. Evaluation of fine needle aspiration biopsy in the diagnosis of breast lesions. Ind J Pathol Microbial. 1981;24:100-6.

Stavric GD, Tevcev DT, Kafandjiev DR , Novak JJ. Aspiration biopsy cytologic method in diagnosis of breast lesion, a critical review 250 cases. Acta cytol. 1973;17:188-90.

Feicher GE. Stastical analysis and cyto histologic correlations. Acta cytologica. 1995;39:327- 47.

Das DK. Fine needle aspiration cytology diagnosis of male breast lesions. Acta cytologica. 1995;39:870-6.

Lilleng R. Assessment of fine needle aspiration cytology and histopathology for diagnosing male breast masses. 1995;39:877- 81.

Amrikachi M, Green LK, Rone R, Ramzy I. Cytological features and diagnostic pitfalls in fine needle aspirates. Acta cytol. 2001;45:948-52.

Park IA. Fine needle aspiration cytology of palpable breast lesion; histologic subtypes in false negative cases. Acta cytologica. 1997;41:1131-7.

Wollenberg NJ. Fine needle aspiration cytology of the breast. A review of 321 cases with stastical evaluation. Acta cytologica. 1985;29:425-9.