Study of relation of serum magnesium level with glycemic control in diabetes mellitus

Authors

  • Subrata Halder Assistant Professor, Department of Medicine, IPGME & R, Kolkata, West Bengal
  • Koushik Roy Department of Medicine, Mathabhanga S.D Hospital, Cooch Behar, West Bengal
  • Kaushik Biswas Consultant Endocrinologist, Department of Endocrinology, The Mission Hospital, Durgapur, West Bengal
  • Priyankar Biswas Department of Medicine, Santipur State General Hospital, Nadia, West Bengal
  • Ramita Sarkar Senior resident, Department of Medicine, IPGME & R, Kolkata, West Bengal

DOI:

https://doi.org/10.18203/2320-6012.ijrms20163305

Keywords:

Type 2 diabetes mellitus, Fasting blood sugar, Post prandial blood sugar, Glycosylated hemoglobin (HbA1c), Magnesium, Body mass index

Abstract

Background: Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Several distinct types of DM are caused by a complex interaction of genetics and environmental factors. This study was done to evaluate the relation between serum magnesium and glycemic control in diabetics.

Methods: 50 patients of T2DM were included this study. Detailed history, physical examination and relevant systemic examination were performed and necessary laboratory tests FBS, PPBS, HbA1c, magnesium level were done

Results: The mean age (mean± SD) of the patients was 49.82±7.38 years with range 29-58 years and the median age was 51 years and Male 32 (64%), Female 18 (36%), M:F= 1.78:1. In this study, statistically significant correlation was found between level of magnesium and age (p=0.04). In present study no statistically significant association was found between level of magnesium and sex (p=0.738). In high magnesium level (≥1.7), mean BMI 25.08±2.82 whereas mean BMI 24.25±2.87 in low magnesium level (<1.7) and this difference was not statistically significant (p=0.308). Mean difference of FBS with magnesium level was statistically significant (p<0.001) and mean difference of PPBS with magnesium level was also statistically significant (p<0.001). It was also found that mean difference of HbA1c level with magnesium level was statistically significant (p<0.001).

Conclusions: This study clearly depicts that in diabetes mellitus serum magnesium levels had a positive correlation with glycemic control. Serum levels of magnesium have been found to correlate inversely with fasting blood glucose concentration, post prandial blood glucose concentration and the percentage of HbA1c. The study also establishes a positive correlation of magnesium with age.

References

Powers AC. Chapter 417. Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology: Kasper Dennis, Fauci Anthony, Hauser Stephen, Longo Dan, Jameson Larry. Harrison’s Principles of Internal Medicine. 19th ed. NewYork: McGraw Hill. 2015:2399-400.

Kareem I, Jaweed SA, Bardapurkar JS, Patil VP. Study of magnesium, glycosylated hemoglobin and lipid profile in Diabetic Retinopathy. Indian J Clini biochemistry. 2004;19(2):124-7.

Waltt MK, Zimmermann MB, Spinas GA, Hurrell RF. Low plasma magnesiumin type 2 diabetes. Swiss Med Wkly. 2003;133:289-92.

Lopez-Ridaura R, Willett WC, Rimm EB, Liu S, Stampfer MJ, Manson JE, et al. Magnesium intake and risk of type 2 diabetes mellitus in men and women. Diabetes Care. 2004;27:134-40.

Huerta MG, Holmes VF, Roemenich JN. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care. 2005;28:1175-81.

Djurhuus MS, Gram J, Peterson PH, Klitgaard NA, Bollerslev J, Beck NH. Insulin increases renal magnesium depletion: a possible cause of magnesium depletion in hyperinsulinemic states. Diabet med. 1995;12:664-9.

Paolisso G, Scheen A,D’ Onfrio F, Lefebvre P. Magnesium and glucose. Diabetologia. 1990;33:511-4.

Yajnik CS, Smith RF, Hockaday TD, Ward NI. Fasting plasma magnesium concentrations and glucose disposal in diabetes. BMJ. 1984;288:1032-4.

Hatwal A, Gujral AS, Bhatia RP, Agarwal JK, Bajpai HS. Association of hypomagnesemia with diabetic retinopathy. Acta Ophtalmol. 1989;67:714-6.

Sasaki S, Oshima T, Matsuura H. Abnormal magnesium status in patients with cardiovascular diseases. Clin Sci (Colch). 2000;98:175-81.

Paolisso G, Passariello N, Pizza G, Marrazzo G, Giunta R, Sgambato S, et al. Dietary magnesium replacements improve B-cell response to glucose and arginine in elderly non-insulin dependent diabetic subjects. Acta endocrinol. 1989;121:16-20.

Yajnick CS, Smith RF, Hockaday TDR, Ward NI. Fasting plasma magnesium concentration and glucose disposal in diabetes. BMJ. 1984;288:1032-4.

Alzaida A, Dinneen SF, Moyer TP, Rizza RA. Effects of insulin on plasma magnesium in noninsulin dependant diabetes mellitus – evidence for insulin ressitance. J Clin Endocrinol Metab. 1995;80:1376-81.

Schlienger Rude RK. Magnesium deficiency and diabetes mellitus – causes and effects. Postgrad Med J. 1992;92:217-24.

Grafton G, Baxter MA, Sheppard MC. Effects of magnesium on sodium dependant inositol transport. Diabetes. 1992;41:35-9.

Nadler JL, Buchnan T, Natarajan R, Antonipillai I, Bergman R, Rude RK. Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension. 1993;21:1024-9.

Lal J, Vasudev K, Kela AK, Jain SK. Effect of oral magnesium supplementation on lipid profile and blood glucose of patients with type 2 diabetes mellitus. JAPI. 2003;51:37-42.

Walti MK, Zimmermann MB, Hurrell RF. Low plasma magnesium in type-2 diabetes. Swiss Med Wkly. 2003;133:289-92.

Jain AP, Gupta NN, Kumar A. Some metabolic facets of magnesium in diabetes mellitus. J Asso phys Ind. 1976;24:827-30.

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Published

2016-12-19

How to Cite

Halder, S., Roy, K., Biswas, K., Biswas, P., & Sarkar, R. (2016). Study of relation of serum magnesium level with glycemic control in diabetes mellitus. International Journal of Research in Medical Sciences, 4(10), 4429–4433. https://doi.org/10.18203/2320-6012.ijrms20163305

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Original Research Articles