Published: 2016-12-19

Thyroid dysfunction in metabolic syndrome: the ensuing storm

Subhashree Ray, Samir Sahu, Anirban Poddar


Background: Metabolic syndrome was initially defined as a constellation of hypertension, hyperglycemia, android obesity and gout. Thyroid dysfunction is characterized by altered thyroid stimulating hormone levels with normal or altered thyroid hormone levels. The aim of the study was to observe thyroid hormone levels and thyroid stimulating hormone levels in a cohort of patients with established metabolic syndrome and to report significant variations if any.

Methods: 54 established cases of metabolic syndrome satisfying the IDF criteria were included in the study along with 54 ages and sex matched healthy controls.

Results: Amongst the controls 92.6% were euthyroid, 5.6% were hypothyroid, 1.9% were subclinical hypothyroid. Among cases 64.8% were euthyroid. Thyroid dysfunction was found to be prevalent among 35.2% metabolic syndrome patients.

Conclusions: Present study clearly reveals a higher incidence of thyroid dysfunction in metabolic syndrome. Metabolic syndrome and thyroid dysfunction are both considered as independent risk factors for cardiovascular disease. Therefore presence of both these entities in an individual increases the risk of a cardiovascular compromise. Hence assessment of thyroid function in metabolic syndrome might serve as a risk assesment tool to identify individuals predisposed to cardiovascular disease early, thereby resulting in a timely intervention.



Thyroid dysfunction, Metabolic syndrome, Hypothyroidism

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Kylin E. Studies of the hypertension, hyperglycemia, hyper uricemia syndrome. Zentrolbi Internal Medicine. 1923;44:105-27.

Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-607.

World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO Consultation. Part 1:diagnosis and classification of diabetes mellitus. Geneva, Switzerland: World Health Organization; 1999.

Pradeeep BV. Prevalence and correlation of Metabolic syndrome in the adolescents. Indian J community medicine. 2015;10:43-8.

Manopriya, Gounder T. Prevalence of metabolic syndrome in local population in India. J croation society of medical Biochemistry and Laboratory Medicine. 2010;20(2):2049-52.

Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al. Harrison’s Principles of Internal Medicine. 18th ed. USA: McGraw-Hill; 2012.

Daese MD. Effect of thyroxin therapy on serum lipoprotein in patients with mild thyroid failure. J Clin Endocrinol Metab. 2000;22:153-8.

Roos A, Bakker SJ, Links TP, Gans RO, Wolffenbuttel BH. Thyroid Function Is Associated with Components of the Metabolic Syndrome in Euthyroid Subjects. J Clin Endocrinol Metab. 2007;92(2):491-6.

Uzunlulu M, Yorulmaz E, Oguz A: Prevalance of subclinical hypothyroidism in patients with metabolic syndrome. Endocr J. 2007;54:71-6.