Discoid lupus erythematosus with epithelial dysplasia: a case report
Keywords:DLE, Epithelial dysplasia, Immunofluorescence, Potentially malignant disorders
Lupus erythematosus is a classic example of an immunologically mediated condition and is one of the most common of the so called “collagen vascular” or connective tissue diseases. Lupus erythematosus was first described by Biett in 1828 and Kaposi in 1872. Development of squamous cell carcinoma (SCC) can occur in DLE, with about 20 cases reported in the world literature to-date, which led the World Health Organization (WHO) to classify DLE as one of the precancerous conditions. Thus malignant changes in such a condition must be given utmost importance. This article focuses on a rare case of DLE with epithelial dysplasia.
Liu W, Shen ZY, Wang LJ, Hu YH, Shen XM, Zhou ZT, et al. Malignant potential of oral and labial chronic discoid lupus erythematosus: a clinicopathological study of 87 cases. Histopathology. 2011;59(2):292-8.
Neville BW, Damm DD, Allen CM, Bouquot JE, editors. Oral and Maxillofacial Pathology. 2nd ed. Philadelphia, PA: WB Saunders. 2002;12:689-692.
Shklar G, McCarthy PL. Histopathology of oral lesions of discoid lupus erythematosus. A review of 25 cases. Arch Dermatol. 1978;114(7):1031-5.
Ranginwala AM, Chalishazar MM, Panja P, Buddhdev KP, Kale HM. Oral discoid lupus erythematosus: A study of twenty-one cases. J Oral Maxillofac Pathol. 2012;16:368-73.
Lourenco SV, Carvalho FRG, Boggio P, Sotto MN, Vilela MAC, Rivitti EA, et al. Lupus erythematosus: clinical and histopathological study of oral manifestations and immunohistochemical profile of the inflammatory infiltrate. J Cutaneous Pathol. 2007:34:558-64.
Tomich CE. Deposits of immunoglobulins, complement, and fibrinogen in oral lupus erythematosus, lichen planus, and leukoplakia. Oral Surg Oral Med Oral Pathol. 1981;51:603.
Bharti S, Dogra S, Saikia B, Walker RM, Chhabra S, Saikia UN. Immunofluorescence profile of discoid lupus erythematosus. Indian J Pathol Microbiol. 2015;58:479-82.
Gao X, Ma L, Zhou Z, Jian X, Liu W. Podoplanin expression is correlated with the progression of chronic discoid lupus erythematosus to lip squamous cell carcinoma. Int J Surg Pathol. 2016;24:595-9.