Recent progress in migraine and cognitive disorder

Song Xiao-Wen, Cao Lin, Chen Jin-Bo, Wu Xin-Tong


Migraine is a chronic neurovascular disease characterized by recurrent unilateral headache, which induces incapacity. At present, there are many methods to evaluate cognitive function, and the cognitive function scale is commonly used. Recently, event-related potentials, resting state functional magnetic resonance imaging and other new technologies have been widely used to assess the cognitive function of migraine patients because of their high temporal resolution and high spatial resolution. In this paper, we can overview that the research progress of the relationship between migraine and methods of evaluate cognitive function.


Cognitive function, ERP, FMRI, Migraine, Reviews

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Headache Classification Committee of the International Headache S. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629-808.

Burch RC, Loder S, Loder E, Smitherman TA. The prevalence and burden of migraine and severe headache in the United States: updated statistics from government health surveillance studies. Headache. 2015;55(1):21-34.

Buse D, Manack A, Serrano D, Reed M, Varon S, Turkel C, Lipton R. Headache impact of chronic and episodic migraine: results from the American Migraine Prevalence and Prevention study. Headache. 2012;52(1):3-17.

Buse DC, Loder EW, Gorman JA, Stewart WF, Reed ML, Fanning KM et al . Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache. 2013;53(8):1278-99.

Merikangas KR. Contributions of epidemiology to our understanding of migraine. Headache. 2013;53(2):230-46.

Schwedt TJ, Dodick DW. Advanced neuroimaging of migraine. J Lancet Neurol. 2009;8(6):560-8.

Seneviratne U,Chong W,Billimoria PH. Brain white matter hyperintensities in migraine:clinical and radiological correlates. J Clin Neurol Neurosurg. 2013;115(71040-3.

Messina R, Rocca MA, Colombo B, Valsasina P, Horsfield MA, Copetti M et a1. Cortical abnormalities in patients with migraine: a surface-based analysis. J Radiology. 2013;268(1):170-80.

Szabó N, Kincses ZT, Párdutz A Tajti J, Szok D, Tuka B et al. White matter microstructural alterations in migraine: a diffusion-weighted MRI study. J. Pain. 2012;153(3):651-6.

Petrusic I,Zidverc-Trajkovic J.Cortical spreading depression: origins and paths as inferred from the sequence of events during migraine aura. J Funct Neurol. 2014;29(9):207-12.

Bashir A, Lipton RB, Ashina S, Ashina M. Migraine and structural changes in the brain: a systematic review and meta-analysis. J. Neurology. 2013;81(14):1260-8.

Martins IP,Gil-Gouveia R, Silva C. Migraine,headaches,and cognition. J.Headache. 2012,52(10):1471-82.

Kalaydjian A, Zandi PP, Swartz KL, Eaton WW, Lyketsos C.How migraines impact cognitive function:findings from the Baltimore ECA. J. Neurology. 2007;68(17):1417-24.

Baars MA,van Boxtel MP,Jolles J.Migraine does not affect cognitive decline:results from the Maastricht aging study. J.Headache. 2010;50(2):176-84.

Rist PM,Dufouil C,Glymour MM,Tzourio C, Kurth T.Migraine and cognitive decline in the population-based EVA study. J Cephalalgia. 2011;31(12):1291-300.

Rist PM, Kang JH, Buring JE, Glymour MM, Grodstein F, Kurth T. Migraine and cognitive decline among women: prospective cohort study. Bmj. 2012;345:e5027.

Fox MD, Greicius M.Clinical applications of resting state functional connectivity. J Front Syst Neurosci. 2010;4:19.

Xue T,Yuan K,Zhao L,Yu D, Zhao L, Dong T, et al.Intrinsic Brain Network Abnormalities in Migraines without Aura Revealed in Resting-State fMRI. PloS one. 2012;7(12):e52927.

Tessitore A, Russo A, Giordano A, Conte F, Corbo D, De Stefano M, et al. Disrupted default mode network connectivity in migraine without aura. J Headache Pain. 2013;14(1):89.

Tessitore A,Russo A,Conte F,Giordano A, De Stefano M, Lavorgna L.Abnormal Connectivity Within Executive Resting-State Network in Migraine with Aura. Headache. 2015;55(6):794-805.

Boćkowski L1, Sobaniec W, Sołowiej E, Smigielska-Kuzia J. Auditory cognitive event-related potentials in migraine with and without aura in children and adolescents. Neurol Neurochir Pol. 2004;38(1):9-14.

Demarquay G1, Caclin A, Brudon F, Fischer C, Morlet D.Exacerbated attention orienting to auditory stimulation in migraine patients. Clin Neurophysiol. 2011;122(9):1755-63.

Jiang S1, Qu C, Wang F, Liu Y, Qiao Z, Qiu X, et al. Using event-related potential P300 as an electrophysiological marker for differential diagnosis and to predict the progression of mild cognitive impairment: a meta-analysis. Neurol Sci. 2015;36(7):1105-12.

Yang Y, Zhang X, Zhu Y, Dai Y, Liu T, Wang Y. Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270[J]. Neuropsychiatr Dis Treat. 2015;11:1405-11.

Buodo G, Palomba D, Sarlo M, Naccarella C, Battistella PA. Auditory event-related potentials and reaction times in migraine children. Cephalalgia. 2004;24(7):554-63.

Andreatta M, Puschmann AK, Sommer C, Weyers P, Pauli P, Mühlberger A. Altered processing of emotional stimuli in migraine: An event-related potential study. Cephalalgia. 2012;32(15):1101-8.

Steppacher I, Schindler S, Kissler J. Higher, faster, worse? An event-related potentials study of affective picture processing in migraine. Cephalalgia. 2016;36(3):249-57.

Siniatchkin M, Gerber-von Muiler G, Darabanea-nu S, Petermann F, Stephani U, Gerber WD. Behavioural treatment programme contributes to normalization of contingent negative variation in children with migraine. Cephalalgia. Cephalalgia. 2011;31(5):562-72.

Kropp P, Gerber WD. Is increased amplitude of contingent negative variation in migraine due to cortical hyperactivity or to reduced habituation? Cephalalgia. 1993;13(1):37-41.

Coppola G,Pierelli F, Schoenen J. Habituation and migraine. Neurobio Learn Mem. 2009;92(2):249-95.

Brighina F, Cosentino G, Fierro B. Habituation or lack of habituation: What is really lacking in migraine?. Clin Neurophysiol.2016;127(1):19-20.

Mickleborough MJ, Chapman CM, Toma AS, Handy TC. Cognitive processing of visual images in migraine populations in between headache attacks. Brain Res. 2014;1582:167-75.

de Tommaso M, Federici A, Franco G, Ricci K, Lorenzo M, Delussi M. Suggestion and pain in migraine: a study by laser evoked potentials. CNS Neurol Disord Drug Targets. 2012;11(2):110-26.