A comparative study of dermatoglyphic markers in schizophrenia patients and normal controls
Keywords:ATD Angle, Dermatoglyphics, Schizophrenia, TABRC, TFRC
Background: Schizophrenia is a complex mental illness with multiple etiological factors. Prenatal insult to the developing foetus has been implicated as a major risk factor for the genesis of schizophrenia, according to the neuro-developmental model. As the brain and skin are ectodermal derivatives, insult to developing brain is reflected in several dermatoglyphic markers.
Methods: Total finger ridge count (TFRC), Total A-B ridge count (TABRC) and ATD Angle of 100 patients diagnosed with schizophrenia were compared with 100 age and sex matched healthy controls.
Results: Statistically significant differences were observed in the values recorded and compared between healthy controls and schizophrenia patients.
Conclusions: This study shows the correlation between abnormalities in dermatoglyphic patterns and development of schizophrenia.
Cummins H, Midlo C. Methods of printing: Ink method. In: Cummins H, Midlo C, eds. Finger Prints of Palms and Soles: an Introduction to Dermatoglyphics. 1st ed. Philadelphia, PA: Blakiston Company; 1943:45.
Mednick, SA, Machon RA, Huttunen MO, Bonett, D. (Adult schizophrenia following prenatal exposure to an influenza epidemic. Archives of general psychiatry.1988;45(2):189-92.
van Os, J, Woodruff, PW, Fañanas L. Ahmad F, Shuriquie N, Howard R. et al Association between cerebral structural abnormalities and dermatoglyphic ridge counts in schizophrenia. Comprehensive psychiatry.2000;41(5):380-4.
van Os, J, Woodruff PW, Fañanas L, Ahmad F, Shuriquie N. Howard R, Murray RM. Association between cerebral structural abnormalities and dermatoglyphic ridge counts in schizophrenia. Comprehensive psychiatry. 2000;41(5):380-4.
Fearon, P, Lane A, Airie M, Scannell J. McGowan, A, Byrne M, et al Is reduced dermatoglyphic a-b ridge count a reliable marker of developmental impairment in schizophrenia?. Schizophrenia research. 2001;50(3):151-7.
Murray M, Lewis SW. Is schizophrenia a neurodevelopmental disorder? British Medical Journal (Clinical Research Ed.). 1987;295(6600):681.
Bramon E, Walshe M, McDonald C, Martín B, Toulopoulou T, Wickham H et al. Dermatoglyphics and schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count. Schizophrenia research. 2005;75(2):399-404.
Green, MF, Bracha HS, Satz P, and Christenson CD. Preliminary evidence for an association between minor physical anomalies and second trimester neurodevelopment in schizophrenia. Psychiatry research.1994;53(2):119-27.
Rosa A, Fañanás L, Van Os J, Ribchester T, Davies, N, Arias B et al Further evidence that congenital dermatoglyphic abnormalities are associated with psychosis: a twin study. Schizophrenia bulletin. 2002;28(4):697.
Holt S. The Genetics of Dermal Ridges, Charles C Thomas. Springfield, Illinois; 1968
Penrose LS. Medical significance of finger-prints and related phenomena. British Med J. 1968;2(5601):321.
Páez F, Apiquian R, Fresán A, Puig A, Orozco B, De la Fuente JR. et al. Dermatoglyphic study of positive and negative symptoms in schizophrenia. Salud Mental. 2001;24(1):28-32.
Chok, J, Kwapil TR, Scheuermann A. Dermatoglyphic anomalies in psychometrically identified schizotypic young adults. Schizophrenia research. 2005;72(2):205-14.
Avila MT, Sherr J, Valentine LE, Blaxton TA, Thaker GK. Neurodevelopmental interactions conferring risk for schizophrenia: a study of dermatoglyphic markers in patients and relatives. Schizophrenia bulletin. 2003;29(3):595.
Divakaran A, Narayanaswamy JC, Kalmadi SV, Narayan V, Rao NP, Venkatasubramanian G. Parent-of-origin effect in schizophrenia and non-affective psychoses: Evidence from dermatoglyphics. Indian J Psycholo Med. 2013;35(3):260.
Golembo-Smith S1, Walder DJ, Daly MP, Mittal VA, Kline E, Reeves G, Schiffman J. The presentation of dermatoglyphic abnormalities in schizophrenia: a meta-analytic review. Schizophr Res. 2012;142(1-3):1-11.
Turek, S. Dermatoglyphics and schizophrenia: analysis of quantitative traits. Coll Anthropol. 1990;14(1):137-50.
Rose RJ, Reed T, Bogle A. Asymmetry of a-b ridge count and behavioural discordance of monozygotic twins. Behav Genet. 1987;17(2):125-40
Sengupta S, Bhuyan SD.). Palmar dermatoglyphics in schizophrenia. Indian J Psychiatry. 1995;37(2):86.
Fearon P, Lane A, Airie M, Scannell J, McGowan, A, Byrne M, et al Is reduced dermatoglyphic a-b ridge count a reliable marker of developmental impairment in schizophrenia. Schizophr Res. 2001;50(3):151-7.
Ozyurt B, Songur A, Sarsilmaz M, Akyol O, Namli M, Demirel R. Dermatoglyphics as markers of prenatal disturbances in schizophrenia: a case-control study. Turk J Med Sci. 2010;40(6):917-24.
Dang J, Huo Z, Peng L, Chen Y, Jiao H, Lu Hong et al. Fluctuating asymmetry of dermatoglyphic ab ridge count in individuals with schizophrenia. 2007.
Sawant, SU, Kolekar SM, Jyothi, P. Dermatoglyphics in male patients with Schizophrenia. IJRTST. 2013;6(2):109-14.
Mellor, CS. Dermatoglyphic evidence of fluctuating asymmetry in schizophrenia. Br J Psychiatry. 1992;160:467-72