The relationship between ABO blood groups and gene mutations frequently observed in Familial Mediterranean Fever


  • Hatice Terzi Department of of Hematology-Internal Medicine, Cumhuriyet University Medical Faculty, Sivas, Turkey
  • Ali Şahin Department of Rheumatology- Internal Medicine, Cumhuriyet University Medical Faculty, Sivas, Turkey
  • Can Hüzmeli Department of Nephrology, Cumhuriyet University Medical Faculty, Sivas, Turkey
  • Ahmet Kerim Türesin Department of Internal Medicine, Cumhuriyet University Medical Faculty, Sivas, Turkey
  • Gökhan Bağci Department of Biology, Cumhuriyet University Medical Faculty, Sivas, Turkey
  • Mehmet Şencan Department of of Hematology-Internal Medicine, Cumhuriyet University Medical Faculty, Sivas, Turkey



Blood groups, Familial Mediterranean fever, Genetic mutation


Background: The purpose of this study was to investigate the relationship between the genetic mutations, which are frequently detected and known to cause familial Mediterranean fever (FMF) disease, with ABO blood groups.

Methods: There were 271 patients with FMF diagnosis and 271 healthy control subject enrolled in the study. The medical files of each case were screened retrospectively and demographic characteristics, genetic mutations, and ABO blood groups were recorded.

Results: No statistically significant difference was detected between the two groups with respect to their gender and age (p>0/05). When patient and healthy control groups were compared based on ABO blood groups, the study groups were observed to differ significantly with respect to B blood group (p=0.008). In the patient group, a considerable relationship could not have been found when the gene mutations were compared based on blood groups, either for E148Q (n=64) and M694V (n=142) genes (p>0.05). However, a considerable difference was observed for V726A (n=58) gene; B blood group was more frequently observed among those who were detected to have V726A mutation (p=0.022).

Conclusions: In present study cohort, blood type B was more frequent among FMF patients. We observed that there could be a significant association between V726A mutation and ABO blood groups.


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How to Cite

Terzi, H., Şahin, A., Hüzmeli, C., Türesin, A. K., Bağci, G., & Şencan, M. (2017). The relationship between ABO blood groups and gene mutations frequently observed in Familial Mediterranean Fever. International Journal of Research in Medical Sciences, 5(4), 1380–1383.



Original Research Articles