Published: 2017-03-28

Mean platelet volume as an indicator of severity of hypertensive retinopathy in hypertensive subjects

Vishal Yadav, Pragya Jain, Abhishek Singhai, Rajesh Kumar Jha


Background: Hypertensive retinopathy (HR) represents the ophthalmic findings of end-organ damage secondary to systemic arterial hypertension. Platelets play a crucial role in the pathogenesis of atherosclerotic complications, contributing to thrombus formation or apposition after plaque rupture. The aim of our study was to investigate whether Mean platelet volume (MPV) is associated with the severity of hypertensive retinopathy in hypertensive patients.

Methods: This cross-sectional study was conducted in Department of Medicine of SAMC and PGI, Indore. Total 250 adult hypertensive patients (BP >140/90 mm Hg or taking antihypertensive drugs) recruited for the study.

Results: Of the 250 subjects, 158 (63.2%) were male and 92 (36.8%) were female. Elevated MPV >11.5 femtoliter was observed in 84 cases (33.6%). There was statistically significant relationship between the grade of retinopathy and elevated MPV in hypertensive subjects. (r = 0.52, P <0.001).

Conclusions: We described a relation between MPV and HR (probably first time in Indian patients). Measurement of MPV is easy to establish and therefore might serve as a valuable predictor of a worse outcome in microvascular complications.


Atherosclerosis, Hypertension, Platelets

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Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999;340:115-26.

Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Haematol. 1992;14:281-7.

Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7:157-61.

Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217-23.

Forouzanfar MH, Alexander L, Anderson HR, Bachman VF, Biryukov S, Brauer M, et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(10010):2287-323.

GBD 2013Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117-71.

Gandhi SK, Powers JC, Nomeir AM, Fowle K, Kitzman DW, Rankin KM, et al. The pathogenesis of acute pulmonary edema associated with hypertension. N Engl J Med. 2001;344:17-22.

Coban E, Adanir H, Bilgin D. The association of mean platelet volume levels with hypertensive retinopathy. Platelets. 2008;19:115-8.

Coban E, Yazicioglu G, Berkant Avci A, Akcit F. The mean platelet volume in patients with essential and white coat hypertension. Platelets. 2005;16:435-8.