Comparative study of serum urea, creatinine and C-reactive protein level in chronic kidney disease patients with healthy subjects

Dileep Singh Nirwan, R. K. Vyas, Sunil Jain


Background: Chronic diseases are a leading cause of morbidity and mortality in India. Globally, chronic kidney disease is the 12th cause of death and the 17th cause of disability, respectively. CKD is defined as kidney damage or glomerular filtration rate (GFR) <60 mL/min/1.73 m2 for 3 months or more, irrespective of cause. The present study aimed to find out correlation between serum urea, creatinine and C-reactive protein (CRP) level among patients suffering from chronic kidney disease in an urban based tertiary care hospital in Bikaner, western Rajasthan, India.

Methods: This study was conducted at Sardar Patel Medical College and Associated Hospitals at Bikaner, Rajasthan from August 2015 to December 2016. There were 50 cases and 50 controls in the age groups from 10 to 60 yearrs. We took fresh samples and performed required tests following standard protocol. CRP has been done by Antigen Antibody reaction (latex method). RFT has been performed on semi-automatic analyzer.

Results: Levels of serum urea and creatinine were significantly raised in CKD patients (p-value<0.005) and CRP level was raised in 52% cases. While 48% cases having normal level %), which requires further study.  Renal function tests were significantly higher in cases than controls.

Conclusions: Serum creatinine and urea level were significantly higher in cases as compared to control group.


CRP, Chronic kidney disease, Creatinine, Urea

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Sicree R, Shaw J, Zimmet P. Diabetes and impaired glucose tolerance. In: Gan D (Ed). Diabetes Atlas, 3rd edition. Brussels: International Diabetes Federation. 2006:15-109.

Eckardt KU, Coresh J, Devuyst O, Johnson RJ, Kottgen A, Levey AS, et al. Evolving importance of kidney disease: from subspecialty to global health burden. Lancet. 2013;382(9887):158-69.

Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298(17):2038-47.

Bash LD, Coresh J, Kottgen A, Parekh RS, Fulop T, Wang Y, Astor BC. Defining incident chronic kidney disease in the research setting: The ARIC Study. AmJ epidemiology. 2009;170(4):414-24.

Grams ME, Chow EK, Segev DL, Coresh J. Lifetime incidence of CKD stages 3-5 in the United States. American journal of kidney diseases. The official J National Kidney Foundation. 2013;62(2):245-52.

Peralta CA, Katz R, DeBoer I, Ix J, Sarnak M, Kramer H, et al. Racial and ethnic differences in kidney function decline among persons without chronic kidney disease. J American Society of Nephrology. 2011;22(7):1327-34.

Levey AS, Eckardt KU, Tsukamoto Y, Kidney Int. Kidney definition and classification of chronic kidney disease : a position statement from kidney disease. Improving Global Outcomes (KDIGO). 2005;67(6):2089-100.

CKD registry of India: Indian Society of Nephrology. Available from [Accessed September, 2012].

Garg AX, Blake PG, Clark WF, Clase CM, Haynes RB, Moist LM. Association between renal insufficiency and malnutrition in older adults: results from the NHANES III. Kidney international. 2001;60(5):1867-74.

Shlipak MG, Fried LF, Crump C, Bleyer AJ, Manolio TA, Tracy RP, et al. Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency. Circulation. 2003;107(1):87-92.

Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135-43.

Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557-65.

Xia Y, Peng C, Zhou Z, Cheng P, Sun L, Peng Y, Xiao P. Clinical significance of urea, creatinine and uric acid levels in patients with chronic kidney disease. J Central South University. Medical sciences. 2012;37(11):1171-6.

Nagarajarao H, Taylor HA, Benjamin EJ, Taylor JK, Sarpong D, Akyllbekova EL, et al. The Relation of C-reactive Protein to Chronic Kidney Disease in African Americans: The Jackson Heart Study. Circulation. 2007;116(Suppl 16):800.

Fox ER, Benjamin EJ, Sarpong DF, Nagarajarao H, Taylor JK, Steffes MW, et al. The relation of C-reactive protein to chronic kidney disease in African Americans: the Jackson Heart Study. BMC Nephrology. 2010;11(1):1.