Seroprevalence trends of transfusion transmitted infections among blood donors in a tertiary care hospital of Himachal Pradesh, India

Amit Sachdeva, Anmol Gupta, Brij Sharma, Deepak Sharma, Neetu Sharma


Background: Transfusion transmitted infections (TTIs) is a major concern for patients and physicians worldwide. Blood banks in all health care institutions worldwide screen blood for TTIs and ensure that only non-reactive blood is released for clinical use. The present study aimed to study the seroprevalence and trends of transfusion transmitted infections in blood donors in Shimla district of Himachal Pradesh, India.

Methods: retrospective review of blood donor’s hospital records (replacement donors and as voluntary donors) covering the period January 2008 to December 2014 was conducted. The serological results for Hepatitis B, Hepatitis C, HIV, syphilis and malaria were retrieved.

Results: A total of 39,083 blood donors of both sexes attended the blood bank during this period. Overall, HBC, HIV, syphilis and malaria rate for blood donors was found to be 0.45%. 0.16%, 0.08%, 0.07% and 0.003% respectively. There is a downward trend in sereoprevalence of all screened TTIs namely HBV, HCV, HIV and syphilis and malaria from 2008-2011.

Conclusions: The study exhibits that over a period of years there is rise in voluntary blood donations which is heartening and encouraging. Trend analysis for prevalence TTIs among blood donors has shown a decreasing trend. It is recommended that continual quality assured screening of donated blood should be carried out as per the prescribed norms to deal with acquired TTI's.



Seroprevalence, Transfusion transmissible infections, Voluntary and replacement blood donors

Full Text:



World Health Organization. Blood safety and availability. Available from URL: mediacentre/ factsheets/ fs279/en/. Accessed on 21-6-2015.

WHO Global Database on Blood Safety, 2004–2005 report. Geneva, World Health Organization. 2008.

Srikrishna A, Sitalakshmi S, Damodar P. How safe are our safe donors? Indian J Pathol Microbiol. 1999;42:411-6.

Voluntary Blood Donation Programme - an Operational Guideline, National AIDS Control Organization, Ministry of Health and Family Welfare Government of India, New Delhi, India. 2007. Available from URL: upload/ Policies%20&%20Guidelines/ 29,%20 voluntary% 20blood%20donation.pdf. Accessed on 21-6-2015.

Gupta N, Kumar V, Kaur A. Seroprevalence of HIV, HBV, HCV and syphilis in voluntary blood donors. Indian J Med Sci. 2004;58:255-7.

Ganesh PPCK, Jayashree K, Manjunath GV. Seroprevalence and trends in transfusion transmitted infections among blood donors in a University hospital blood bank: a five year study. Indian J Hematol Blood Transfus. 2011;27:1-6.

Mahapatra S. Prevalence of Transfusion Transmitted Infections Giving Importance to HIV in Screening of Healthy Blood Donors and the Challenges Ahead. Clin Res HIV/AIDS. 2015;2(1):1013.

Pailoor K, Keshava SM, Rai P. A Retrospective Study of Screening of Common Transfusion Transmitted Infections in the Blood Bank of a Tertiary Care Centre. J Blood Disorders Transf. 2015;6:267.

Sukrutha Gopal R, Radhika Chowdary D, Anil Kumar B. Seroprevalence of transfusion transmissible infections among healthy blood donors at KIMS blood bank. J Med Sci Res. 2014;2:137-9.

Sawke N, Sawke GK, Chawla S. Seroprevalence of common transfusion – Transmitted infections among blood donors. People’s J Sci Res. 2010;3(1):5-7

Pahuja S, Sharma M, Baitha B, Jain M. Prevalence and trends of markers of hepatitis C virus, hepatitis B virus and HIV in Delhi blood donors. A hospital based study. Jpn J Inf. Dis. 2007;60:389-91.

Giri PA, Deshpande JD, Phalke DB, Karle LB. Seroprevalence of transfusion transmissible infections among voluntary blood donors at a tertiary care teaching hospital in rural area of India. J Family Med Prim Care. 2012;1(1):48-51.

Karmakar PR, Shrivastava P, Ray TG. Seroprevalence of transfusion transmissible infections among blood donors at the blood bank of a Medical College of Kolkata. Indian J Public Health. 2014;58(1):61-4.

Mythreyee M, Jayachandran C, Amudhan M et al. Low prevalence of transfusion-transmissible infections among voluntary blood donors in South India. J Infect Dev Ctries. 2011;5:410-2.

Sabharwal ER, Biswas NK, Vishnu Purohit V. Prevalence and patterns of transfusion transmissible infections among blood donors in Sri Ganganagar, Rajasthan, India: - A retrospective study. J Phar Biomed Sci. 2012;15:1-4

Gupta AK, Bhardwaj AK, Kaushal ML. Sero prevalence of TTI’s in Shimla Blood Banks. The Antiseptic. 2005;102:339-40.

Negi G, Gaur DS. Trends of transfusion transmissible diseases among blood donors at Uttarakhand, India. Indian J Community Med. 2014;39:183-6.