Study of the correlation between platelet parameters in the patients with coronary heart disease

Mohamed Abdirahman Abdinur, Xie Yong, Kong Lingcai, Farah Abdidahir Mohamud, Jamac Abdidahir Mohamud, Abdinasir Sharif Isse


Background: The incidence and development of coronary heart disease are ultimately associated with the size and function of platelet. Present study aimed to determine the clinical value of platelet distribution width as an indicator for prediction or risk stratification of coronary heart disease by retrospective analysis of particular population.

Methods: This retrospective study covered a total of 150 patients that were included due to a variety of indications for coronary angiography. The control group N-CHD was the patients without coronary heart disease confirmed by coronary angiography examination. The S-CHD group was patients with Stable type coronary heart disease confirmed diagnosis by coronary angiography examination. Study group 2 defined as group ACS were the patients who suffering acute coronary syndrome episode at admission and received coronary angiography and interventional treatment thereafter.

Results: The PDW of S-CHD and ACS were 13.85±2.68 and 13.89±1.16, respectively, and there was no significant difference, while the PDW of the N-CHD group was 12.58±2.11, and the values of the first two groups were significantly higher than those of the N-CHD group. In addition, the MPV and P-LCR of S-CHD were significantly higher than those of N-CHD group (11.14±1.17 versus 10.51±0.91 and 32.71±9.99 versus 28.41±7.69), respectively P<0.01; but there was no significant difference between S-CHD and ACS.

Conclusions: PDW, MPV, and P-LCR are the platelet volume indicators that can reflex the variability of circulation platelets; their increase was highly and positively associated with Coronary heart disease.


Acute coronary syndrome, Coronary heart disease, Platelet distribution width

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Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart disease and stroke statistics- 2017 update: a report from the American Heart Association. Circulation. 2017;135(10):e146-603.

Sun XP, Li BY, Li J, Zhu WW, Hua Q. Impact of mean platelet volume on long-term mortality in Chinese patients with ST-elevation myocardial infarction. Scientific reports. 2016;6.

Bergoli LC, Castanho ES, Gonçalves SC, Wainstein RV, Piardi D, Araújo G, et al. Mean platelet volume as a predictor of major cardiovascular outcomes and final coronary flow in patients undergoing primary percutaneous coronary intervention. Revista Brasil Cardiol Invasiva. 2014;22(3):240-4.

Martin JF, Bath PM, Burr ML. Influence of platelet size on outcome after myocardial infarction. Lancet. 1991;338(8780):1409-11.

Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8(1):148-56.

Ross R, Glomset JA. Atherosclerosis and the arterial smooth muscle cell: proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science. 1973;180:1332-9.

Ranjith MP, Raj RD, Mathew D, George B, Krishnan MN. Mean platelet volume and cardiovascular outcomes in acute myocardial infarction. Heart Asia. 2016;8(1):16-20.

Bennett MR, Sinha S, Owens GK. Vascular smooth muscle cells in atherosclerosis. Circ Res. 2016;118:692-702.

Ross R, Glomset JA. Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science. 1973;180(4093):1332-9.

Ross R. Atherosclerosis- an inflammatory disease. N Engl J Med. 1999;340:115-26.

Sigurdsson AF. Low-density lipoprotein (LDL) in atherosclerosis and heart Disease. 2017. Available at Accessed on April 7, 2017.

Kabbany MT, Aditya A. Joshi, Nehal N. Mehta; et al Cardiovascular Diseases in Chronic Inflammatory Disorders, Am coll of Cardiology, Jul 18, 2016.

Ludewig B, Zinkernagel RM, Hans H. Arterial inflammation and atherosclerosis. Trends Cardiovasc Med. 2002;12:154-9.

Bombeli T, Schwartz BR, Harlan JM. Adhesion of activated platelets to endothelial cells: evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 (ICAM-1), alphavbeta3 integrin, and GPIbalpha. J Exp Med. 1998;187(3):329-39.