Transfusion effect of random donor platelet and single donor platelet in thrombocytopenic patients at tertiary care hospital of South Gujarat

Authors

  • Chirag A. Unagar Department of Immuno-Hematology and Blood Transfusion, Government Medical College, Surat, Gujarat, India
  • Snehal G. Patel Department of Immuno-Hematology and Blood Transfusion, Government Medical College, Surat, Gujarat, India
  • Kamal A. Patel Department of Immuno-Hematology and Blood Transfusion, Government Medical College, Surat, Gujarat, India
  • Amrish N. Pandya Department of Immuno-Hematology and Blood Transfusion, Government Medical College, Surat, Gujarat, India
  • Mayur A. Jarag Department of Immuno-Hematology and Blood Transfusion, Government Medical College, Surat, Gujarat, India
  • Jitendra N. Patel, Department of Immuno-Hematology and Blood Transfusion, Government Medical College, Surat, Gujarat, India
  • Sangita J. Wadhwani Department of Immuno-Hematology and Blood Transfusion, Government Medical College, Surat, Gujarat, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20172983

Keywords:

Corrected count increment, Percentage recovery, Platelet apheresis, Random donor platelet, Single donor platelet

Abstract

Background: Platelet transfusion plays a key role in therapy for the patients with thrombocytopenia. Superiority of Single donor platelet (SDP) over Random donor platelet (RDP) transfusions is largely assumed, but unproven. Platelet Rich Plasma-Platelet concentrate (PRP-PC) and Apheresis-PC were prepared and their therapeutic efficacy were assessed in thrombocytopenic patients.

Methods: This study included 60 transfusion episodes consisting of 30 SDP and 30 RDP (147units of RDP). The post transfusion efficacy of transfused platelets was assessed at 1 hour and 24 hours by corrected count increment (CCI) and percentage recovery (PR). Paired ‘t’-test was used for statistical analysis and a probability of p<0.05 was used to reject null hypothesis.

Results: The mean platelet dose of SDP (n=30) and RDP (n=30) was 2.86±1.05 x 1011 and 2.36±0.54 x 1011 respectively. The mean platelet increments of SDP at 1 hour and 24 hours were 38±18.1 x 103/μl and 37.3±20.7x 103/μl. The mean platelet increments of RDP at 1 hour and 24 hours were 28.5±11.4 x 103/μl and 26 ±11.6 x 103/μl. The mean CCI of SDP at 1hour and 24 hours were 21.4 ±7.3 x 103/μl and 20.8±7.4 x 103/μl respectively. The mean CCI of RDP at 1hour and 24 hours were 18.5±6.3x 103/μl and 17.4±7.6 x 103/μl respectively.

Conclusions: Post-transfusion increments were significantly higher in patients who received SDP as compared to RDP, but the CCI and PR were comparable in both groups of patients.

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Published

2017-06-24

How to Cite

Unagar, C. A., Patel, S. G., Patel, K. A., Pandya, A. N., Jarag, M. A., Patel, J. N., & Wadhwani, S. J. (2017). Transfusion effect of random donor platelet and single donor platelet in thrombocytopenic patients at tertiary care hospital of South Gujarat. International Journal of Research in Medical Sciences, 5(7), 3033–3037. https://doi.org/10.18203/2320-6012.ijrms20172983

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Original Research Articles