DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20163818

Portal vein thrombosis with protein C-S deficiency in a non-cirrhotic patient

Sheetal Deshpande, Smita Patil, Manish Pendse, Prashant Kashyap, Dhaval Dave

Abstract


There are several conditions that can lead to portal vein thrombosis (PVT), including including infection, malignancies, and coagulation disorders. Anew condition of interest is protein C and S deficiencies, associated with hypercoagulation and recurrent venous thromboembolism. We report the case of a non-cirrhotic 24-year-old male diagnosed with acute superior mesenteric vein thrombosis and PVT and combined deficiencies in proteins C and S.


Keywords


Portal vein thrombosis, Protein C and S deficiency

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References


Sheen CL, Lamparelli H, Milne A, Green I, Ramage JK. Clinical features, diagnosis and outcome of acute portal vein thrombosis. QJM. 2000;93:531-4.

Hwang S, Kim DY, Kim M, Chon YE, Lee HJ, Park YN, et al. Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis. Korean J Hepatol. 2010;16:176-81.

Denninger MH, Chaït Y, Casadevall N, Hillaire S, Guillin MC, Bezeaud A, et al. Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors. Hepatology. 2000;31:587-91.

Belli L, Romani F, Sansalone CV, Aseni P, Rondinara G. Portal thrombosis in cirrhotics. A retrospective analysis. Ann Surg. 1986;203:286-91.

Denninger MH, Chaït Y, Casadevall N, Hillaire S, Guillin MC, Bezeaud A, et al. Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors. Hepatology. 2000;31:587-91.

Majluf-Cruz A, Hurtado Monroy R, SansoresGarcía L, Labardini-Méndez J. The incidence of protein C deficiency in thrombosis-related portal hypertension. Am J Gastroenterol. 1996;91:976-80.

Ruiz-Argüelles GJ, López-Martínez B, Valdés-Tapia P, Gómez-Rangel JD, Reyes-Núñez V, Garcés-Eisele J. Primary thrombophilia in Mexico. V. A comprehensive prospective study indicates that most cases are multifactorial. Am J Hematol. 2005;78:21-6.

Orozco H, Guraieb E, Takahashi T, Garcia-Tsao G, Hurtado R, Anaya R, et al. Deficiency of protein C in patients with portal vein thrombosis. Hepatology. 1988;8:1110-1.

Valla D, Casadevall N, Huisse MG, Tulliez M, Grange JD, Muller O, et al. Etiology of portal vein thrombosis in adults.A prospective evaluation of primary myeloproliferative disorders. Gastroenterology. 1988;94:1063-9.

Aiach M, Borgel D, Gaussem P, Emmerich J, Alhenc-Gelas M, Gandrille S. Protein C and protein S deficiencies. SeminHematol. 1997;34:205-16.

Hwang S, Kim do Y, Kim M, Chon YE, Lee HJ, Park YN, et al. Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis. Korean J Hepatol. 2010;16:176-81.

Das SK, Ray A, Jana CK, Banerjee N, Khaskil S. Chronic portal vein thrombosis due to combined deficiency of protein C and protein S. J Indian Med Assoc. 2011;109:753-4.