Portal vein thrombosis with protein C-S deficiency in a non-cirrhotic patient

Sheetal Deshpande; Smita Patil; Manish Pendse; Prashant Kashyap; Dhaval Dave

doi:10.18203/2320-6012.ijrms20163818

Authors

Sheetal Deshpande Department General Medicine, D. Y. Patil Hospital & Research Centre, Nerul, Navi Mumbai, Maharashtra, India
Smita Patil Department General Medicine, D. Y. Patil Hospital & Research Centre, Nerul, Navi Mumbai, Maharashtra, India
Manish Pendse Department General Medicine, D. Y. Patil Hospital & Research Centre, Nerul, Navi Mumbai, Maharashtra, India
Prashant Kashyap Department General Medicine, D. Y. Patil Hospital & Research Centre, Nerul, Navi Mumbai, Maharashtra, India
Dhaval Dave Department General Medicine, D. Y. Patil Hospital & Research Centre, Nerul, Navi Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20163818

Keywords:

Portal vein thrombosis, Protein C and S deficiency

Abstract

There are several conditions that can lead to portal vein thrombosis (PVT), including including infection, malignancies, and coagulation disorders. Anew condition of interest is protein C and S deficiencies, associated with hypercoagulation and recurrent venous thromboembolism. We report the case of a non-cirrhotic 24-year-old male diagnosed with acute superior mesenteric vein thrombosis and PVT and combined deficiencies in proteins C and S.

Metrics

Metrics Loading ...

References

Sheen CL, Lamparelli H, Milne A, Green I, Ramage JK. Clinical features, diagnosis and outcome of acute portal vein thrombosis. QJM. 2000;93:531-4.

Hwang S, Kim DY, Kim M, Chon YE, Lee HJ, Park YN, et al. Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis. Korean J Hepatol. 2010;16:176-81.

Denninger MH, Chaït Y, Casadevall N, Hillaire S, Guillin MC, Bezeaud A, et al. Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors. Hepatology. 2000;31:587-91.

Belli L, Romani F, Sansalone CV, Aseni P, Rondinara G. Portal thrombosis in cirrhotics. A retrospective analysis. Ann Surg. 1986;203:286-91.

Denninger MH, Chaït Y, Casadevall N, Hillaire S, Guillin MC, Bezeaud A, et al. Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors. Hepatology. 2000;31:587-91.

Majluf-Cruz A, Hurtado Monroy R, SansoresGarcía L, Labardini-Méndez J. The incidence of protein C deficiency in thrombosis-related portal hypertension. Am J Gastroenterol. 1996;91:976-80.

Ruiz-Argüelles GJ, López-Martínez B, Valdés-Tapia P, Gómez-Rangel JD, Reyes-Núñez V, Garcés-Eisele J. Primary thrombophilia in Mexico. V. A comprehensive prospective study indicates that most cases are multifactorial. Am J Hematol. 2005;78:21-6.

Orozco H, Guraieb E, Takahashi T, Garcia-Tsao G, Hurtado R, Anaya R, et al. Deficiency of protein C in patients with portal vein thrombosis. Hepatology. 1988;8:1110-1.

Valla D, Casadevall N, Huisse MG, Tulliez M, Grange JD, Muller O, et al. Etiology of portal vein thrombosis in adults.A prospective evaluation of primary myeloproliferative disorders. Gastroenterology. 1988;94:1063-9.

Aiach M, Borgel D, Gaussem P, Emmerich J, Alhenc-Gelas M, Gandrille S. Protein C and protein S deficiencies. SeminHematol. 1997;34:205-16.

Hwang S, Kim do Y, Kim M, Chon YE, Lee HJ, Park YN, et al. Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis. Korean J Hepatol. 2010;16:176-81.

Das SK, Ray A, Jana CK, Banerjee N, Khaskil S. Chronic portal vein thrombosis due to combined deficiency of protein C and protein S. J Indian Med Assoc. 2011;109:753-4.