Prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) infections among patients admitted in critical care units in a tertiary care hospital

Authors

  • Arunkumar V. Final Year MBBS Student, Government Vellore Medical College and Hospital, Adukkamparai, Vellore District, Tamil Nadu, India
  • Prabagaravarthanan R. Senior Assistant Professor, Government Vellore Medical College and Hospital, Adukkamparai, Vellore District, Tamil Nadu, India
  • Bhaskar M. Professor and Head, Department of Microbiology, Government Vellore Medical College and Hospital, Adukkamparai, Vellore District, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20172085

Keywords:

CCUs, MRSA, PICU, SICU

Abstract

Background: The emergence of Methicillin-resistant Staphylococcus aureus (MRSA) infections in hospital leads to significant morbidity and mortality. Hence the present study was undertaken to estimate the prevalence of MRSA in critical care units (CCUs) at our centre. The objective of this study was to find the prevalence of MRSA infections in CCUs, to determine their antibiotic profile. And to screen for MRSA in the environment of CCUs in order to find whether they act as a source of infection.

Methods: The present cross-sectional study included 100 patients admitted to various CCUs in our hospital. The clinical specimens (urine, Sputum, pus, blood and CSF) were collected from the admitted patients along with environmental samples from these CCUs. Two samples were collected from each patient and subjected to culture and antibiotic susceptibility testing.

Results: 168 samples from 100 patients were processed. Out of which five pus samples from five different patients admitted in surgical intensive care unit (SICU) were positive for MRSA infection showing 5% prevalence in CCUs. All MRSA strains were sensitive to vancomycin and teicoplanin. Out of 30 environmental swabs, 1 swab taken from paediatric intensive care unit (PICU) showed positivity for MRSA (3%).

Conclusions: CCUs in our hospital have shown 5% prevalence of MRSA among the admitted patients. There was no correlation between environmental MRSA presence and infection in the samples from patient.

References

Clinical and Laboratory Standard Institute (CLSI). Performance standards for antimicrobial susceptibility testing; 16th informational supplement. USA, Wayne. P.A.2009;29(3):M100-S19.

El-Jahl HA, Jallad M, Thwaini AJ. Nasal carriage of methicillin resistance Staphylococcus aureus in individuals exposed and not exposed to hospital environment. Eu J Sci Res. 2008;22(4):570-4.

Sanjana RK. Prevalence and antimicrobial susceptibility a preliminary report. J Col Med Sci Nepal. 2010;6:1.

Joshi S, Ray P, Manchanda V, Bajaj J, Chitnis DS, Gautam V, et al. Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence and susceptibility pattern. Indian J Med Res. 2013;137(2):363-9.

Shrestha B, Pokhrel B, Mohapatra T. Study of nosocomial isolates of Staphylococcus aureus with special reference to methicillin resistant S. aureus in a tertiary care hospital in Nepal. Nepal Med Coll J. 2009;11(2):123-6.

Sim BL, McBryde E, Street AC, Marshall C. Multiple site surveillance cultures as a predictor of methicillin-resistant Staphylococcus aureus infections. Infect Cont Hospital Epidemiol. 2013;34(8):818-24.

Sucilathangam G, Niranjan S, Velvizhi G, Palaniappan N, Anna T. Phenotypic differentiation of BORSA from MRSA: comparison of susceptibility testing methods and MRSA Latex agglutination test. J Pharm Biomed Sci. 2013;27(27):592-8.

Assadullah S, Kakru DK, Thoker MA, Bhat FA, Hussain N, Shah A. Emergence of low level vancomycin resistance in MRSA. Indian J Med Microbiol. 2003;21:196-8.

Fluit AC, Wielders CL, verhoef Jf. Epidemiology and susceptibility of 3051 Staphylococcus aures isolates from 25 university hospitals participating in the European SENTRY study. J Clin Microbiol. 2001;39:3727-32.

Fridkin SK, Gaynes RP. Antimicrobial resistance in intensive care units. Clin Chest Med. 1999;20:303-16.

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Published

2017-05-27

How to Cite

V., A., R., P., & M., B. (2017). Prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) infections among patients admitted in critical care units in a tertiary care hospital. International Journal of Research in Medical Sciences, 5(6), 2362–2366. https://doi.org/10.18203/2320-6012.ijrms20172085

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Section

Original Research Articles