Analysis of treatment outcome in multi-drug resistant tuberculosis patients treated under programmatic conditions

Authors

  • A. K. Janmeja Department of Pulmonary Medicine, Govt. Medical College and Hospital, Chandigarh, India
  • Deepak Aggarwal Department of Pulmonary Medicine, Govt. Medical College and Hospital, Chandigarh, India
  • Ruchika Dhillon Department of Pulmonary Medicine, Govt. Medical College and Hospital, Chandigarh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20172122

Keywords:

Programmatic conditions, MDR-TB, Treatment outcome

Abstract

Background: Programmatic management of MDR-TB has taken over the un-standardized and unsupervised treatment practice in India. However, despite being implemented in whole of country, the data on the program surveillance is scarce.  Hence the present study was sought to evaluate the treatment outcome in patients with MDR TB in Chandigarh being treated under programmatic conditions.

Methods: A retrospective study was carried out by enrolling all MDR-TB patients registered between January 2012 to December 2014. Medical records of 140 patients were scrutinized for necessary information on demographic, clinical parameters and previous TB treatment. Treatment outcomes to Cat IV anti-TB therapy, any interruptions in treatment, adverse drug reactions, culture conversion etc. were evaluated from the records.

Results: Of the 140 patients, 77 (55%) were declared cured, 11 (7.9%) completed treatment, 23 patients (16.4%) died, 13 (9.3%) defaulted on treatment, 5 (3.6%) had treatment failure and 11 (7.9%) were shifted to Cat V therapy. On comparison, BMI, haemoglobin, treatment outcome in previous ATT, treatment adherence and time to sputum culture conversion were significantly different in different treatment outcome groups.

Conclusions: The treatment success rate of MDR‑TB patients have shown improvement under programmatic conditions. Interventions to improve BMI and treatment adherence might further help to improve the success rate.

Author Biographies

A. K. Janmeja, Department of Pulmonary Medicine, Govt. Medical College and Hospital, Chandigarh, India

Professor & Head
Department of Pulmonary Medicine, 
Govt Medical College & Hospital, 
Chandigarh, India

Deepak Aggarwal, Department of Pulmonary Medicine, Govt. Medical College and Hospital, Chandigarh, India

Associate Professor
Department of Pulmonary Medicine,
Govt Medical College & Hospital,
Chandigarh, India

Ruchika Dhillon, Department of Pulmonary Medicine, Govt. Medical College and Hospital, Chandigarh, India

Medical officer- DRTB centre
Department of Pulmonary Medicine, 
Govt Medical College & Hospital, 
Chandigarh, India

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Published

2017-05-27

How to Cite

Janmeja, A. K., Aggarwal, D., & Dhillon, R. (2017). Analysis of treatment outcome in multi-drug resistant tuberculosis patients treated under programmatic conditions. International Journal of Research in Medical Sciences, 5(6), 2401–2405. https://doi.org/10.18203/2320-6012.ijrms20172122

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Section

Original Research Articles