Study of utilization pattern and analysis of efficacy of newer angiotensin receptor blockers in patients with hypertension and type-II diabetes with or without hypertension

Authors

  • Rajashree Samal Department of Pharmacology, SCB Medical College, Cuttack - 753007, Odisha, India
  • Jyoti Prakash Panda Department of Pharmacology, SCB Medical College, Cuttack - 753007, Odisha, India
  • Kali Prasad Pattnaik Department of Pharmacology, SCB Medical College, Cuttack - 753007, Odisha, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20172537

Keywords:

Angiotensin receptor blockers, AT1 receptor, Hypertension, Type-II diabetes mellitus

Abstract

Background: Interventions that target blood pressure control and proteinuria, specifically interruption of the Renin-angiotensin-aldosterone system (RAAS), have been utilized in attenuating cardiovascular complications. Angiotensin receptor blockers (ARBs) have been reported to have certain advantages. The objective of the study was to evaluate and compare the utilization pattern and efficacy of different ARBs in patients with HTN and associated type-II diabetes.

Methods: Hypertensive patients with or without type-II diabetes treated with ARB based regimen were selected.  The BP and 24 hours urinary albumin excretion were analysed at baseline and after three months of treatment.

Results: Mean reduction in systolic blood pressure(SBP) was more with ARBs and calcium channel blocker(CCB) combination. Telmisartan alone and with ACEI reduced diastolic blood pressure (DBP) maximally in diabetic hypertensive patients. Proteinuria was significantly reduced with telmisartan (p<0.001) and olmesartan (p<0.05) based therapy. The side effects were minimal with ARB based therapy. Telmisartan was the costliest among all ARBs

Conclusions: There was suboptimal use of combination therapy in diabetic hypertensive patients.  Telmisartan was having the better control on 24hr urinary albumin excretion.

Author Biography

Rajashree Samal, Department of Pharmacology, SCB Medical College, Cuttack - 753007, Odisha, India

Dept. of Pharmacology

SCB Medical College

Cuttack

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Published

2017-06-24

How to Cite

Samal, R., Panda, J. P., & Pattnaik, K. P. (2017). Study of utilization pattern and analysis of efficacy of newer angiotensin receptor blockers in patients with hypertension and type-II diabetes with or without hypertension. International Journal of Research in Medical Sciences, 5(7), 2931–2937. https://doi.org/10.18203/2320-6012.ijrms20172537

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Original Research Articles