Study of distribution of ABO blood groups in ß-thalassemia patients

Authors

  • Pranoti A. Sinha Department of Physiology, Grant Government Medical College, Byculla, Mumbai-400008, Maharashtra, India
  • Sachin H. Mulkutkar Department of Physiology, Grant Government Medical College, Byculla, Mumbai-400008, Maharashtra, India
  • J. B. Bhavani Medical Superintendent, St. George Hospital, Mumbai-400001, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20173545

Keywords:

ß-thalassemia, Blood groups, Post-disease complication

Abstract

Background: ß-thalassemia is an inherited hematological disorder caused by reduced or absent synthesis of ß globin chains of the hemoglobin which causes hemolysis and impair erythropoiesis. Affected children thus require regular lifelong blood transfusions. Blood group is one of the important and comparatively known parameter today which exhibits a strong correlation with some common diseases like cardiovascular diseases, gastric cancer, HIV infection etc. Aim of this study hence was to study relation between ABO blood groups and ß-thalassemia and to study complications in each blood groups to make it easy to predict the type of population which is more prone or resistant to ß-thalassemia for understanding the regional demand of rare blood groups and to tide over the demands.

Methods: This was a cross sectional, single centric, open labeled, observational study in which 100 patients of ß-thalassemia were screened for their ABO blood groups after permission from institutional ethics committee and informed consent from the patient.

Results: Most common blood group in ß-thalassemia patient is O +ve. Post-disease complication is commonly seen with B +ve. Early onset of beta-thalassemia is seen in A +ve and B +ve. Late onset is seen with O +ve. Severity more with B –ve while O +ve shows disease in less severe form.

Conclusions: On analysis, it was found that the most common blood group getting affected by the disease ß-thalassemia is O +ve with the same people having higher chances of family history of the same disease. Within the family members who have the positive history of the disease, most common was O +ve blood group again.

Author Biography

Pranoti A. Sinha, Department of Physiology, Grant Government Medical College, Byculla, Mumbai-400008, Maharashtra, India

Department of Physiology

References

Mohssin MY, Mahmood AE, Kamal SB, Batah EH. Frequency distribution of hemoglobin variant and ABO blood groups among thalassemia patients from Ibn-Al-Baladi pediatric hospital in Baghdad/Iraq. W J Pharma Pharmaceut Sci. 2015;4(11):31-9.

Sadeghian MH, Keramati MR, Badiei Z, Ravarian M, Ayatollahi H, Rafatpanah H, et al. Alloimmunization among transfusion-dependent thalassemia patients. Asian J Transfusion Sci. 2009;3(2):95-8.

Tahir H, Shahid SA, Mahmood KT. Complications in thalassemia patients receiving blood transfusion. J Biomed Sci Res. 2011;3(1):339-46.

Kumar BA, Kaushik M. Blood group and anemia; exploring new relationship. J Public Health Epidemiol. 2013;5(1):43-5.

Saha AK, Sahadalal BS. Frequency and distribution of blood groups in the donors of a rural hospitals, West Bengal, India. Int J Pharma Bio Sci. 2016;7(1):B414-8.

Iqbal M, Niazi A, Tahir M. Frequency of ABO and Rh blood groups in healthy donors. J Rawalpindi Med Coll. 2009;13(2);92-4.

Mohammadali F, Pourfathollah A. Association of ABO and Rh blood groups to blood borne infections among blood donors in Tehran-Iran. Iranian J Public Health. 2014;43(7):981-9.

Roudbari M, Rad MS, Roudbari S. The survival of beta thalassemia major patients in South east of Iran. Saudi Med J. 2008;29(7):1031-5.

Canatan D, Acar N, Kili B. Rh subgroups and Kell antigens in patients with thalassemia and donors in Turkey. Turkey J Med Sci. 1999:29:155-7.

Roudbari M, Rad MS, Roudbari S. The survival of beta thalassemia major patients in south east of Iran. Saudi Med J. 2008;29(7):1031-5.

Ghori MR, Tayyab M, Raziq F. Frequency of ABO and RhD blood groups in transfusion dependent patients. J Postgraduate Med Institute. 2003;17(2);177-83.

Gundrajukuppam DK, Vijaya SK, Rajendran A, Sarella JD. Prevalence of principal Rh blood group antigen in blood donors at the blood bank of a tertiary care hospital in Southern India. J Clin Diagnostic Res. 2016;10(5):EC7-10.

Abdulghani AS, Salih KM. Distribution of BMI, Blood groups and secretory status among Iraqi patients with beta thalassemia major. J Natural Sci Res. 2016;6(8):42-5.

Vaziri M, Shahshahni HJ, Moqhaddam M, Taghvaee N. Prevalence and specificities of red cells alloantibodies in transfusion-dependent beta thalassemia patients in Yazd. Iranian J Pediatric Hematol Oncol. 2015;5(2):93-9.

Hassan K, Younus M, Ikram N, Naseem L, Zaheer HA. Red cell alloimmunization in repeatedly transfused thalassemia major patients. Int J Pathol. 2004;2(1):16-9.

Downloads

Published

2017-07-26

How to Cite

Sinha, P. A., Mulkutkar, S. H., & Bhavani, J. B. (2017). Study of distribution of ABO blood groups in ß-thalassemia patients. International Journal of Research in Medical Sciences, 5(8), 3479–3483. https://doi.org/10.18203/2320-6012.ijrms20173545

Issue

Section

Original Research Articles