Macrocalcification in thyroid nodule


  • Naina Verma Department of ENT-HNS, IGMC, Shimla, Himachal Pradesh, India
  • Shobha Mohindroo Department of Pathology, IGMC Shimla, Himachal Pradesh, India
  • Ramesh Azad Department of ENT-HNS, IGMC, Shimla, Himachal Pradesh, India
  • N. K. Mohindroo Department of ENT-HNS, IGMC, Shimla, Himachal Pradesh, India



Macrocalcification, Thyroid nodule, Ultrasonography


Background: The thyroid is one of the largest endocrine organs. The prevalence of palpable thyroid nodules increases with age and is 4-7% in a middle-aged population. Objective of present study was to understand if thyroid malignancy is associated with macrocalcification.

Methods: 34 cases were with thyroid nodules were evaluated initially with sonography and then with FNAC, the results of which were given on the basis of Bethesda system.

Results: On USG, 23 (67.6%) nodules had macrocalcifications, 5 (14.7%) had microcalcifications and 6 (17.6%) had both micro as well as macrocalcifications. Cytology of 23 nodules with macrocalcification were non-diagnostic in 8.7%, benign 73.9%, suspicious for malignancy in 8.7 % and malignant in 8.7%. Only 2 lesions with macrocalcification and 1 with both macro and microcalcification came out to be non-diagnostic. 17 lesions with macrocalification were diagnosed as benign, 2 as suspicious for malignancy and 2 as malignant. While 3 lesions with microcalcification were diagnosed as malignant on FNAC and 2 as benign.

Conclusions: Macrocalcification is not a good indicator for malignancy.


Kantasueb S, Sukpan K, Mahanupab P. The study of thyroid lesions and the between histopathological and cytological findings at Maharaj correlation Nakorn Chaing Mai hospital between 2003 and 2007. J Korean Med Sci. 2006;2:469-73.

Wong CK, Wheeler MH. Thyroid nodules, rational management. World J Surg. 2000;34:934-41.

Frates MC, Benson CB, Doubilet PM, Kunreuther E, Contreras M, Cibas ES et al. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endocrinol Metab. 2006;91:3411-7.

Amersor NR, Roy HG, Gill RK. Thyroid swelling- A review of 75 consecutive cases of thyroid with special reference to incidence of malignancy and post-operative complications. Indian J Surg. 1963;25:621-34.

Arora HL, Gupta DP. Geographic pathology of Thyroid Disease in Rajasthan. J Indian Med Assoc. 1967;48:424-28.

Bomeli SR, LeBeau SO, Ferris RL. Evaluation of a thyroid nodule. Otolaryngol Clin North Am. 2010;43:229-38.

Chang S, Joo M, Kim H. Fine Needle Aspiration Biopsy of Thyroid Nodules in Children and Adolescents. J Korean Med Sci. 2006;21:469.

Boelaert K, Horacek J, Holder RL, Watkinson JC, Sheppard MC, Franklyn JA. Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration. J Clin Endocrinol Metab. 2006;91:4295-301.

Stergios A, Polyzos, Kita M, Avramidis A. Thyroid nodules. Stepwise diagnosis and management. Hormones. 2007;6:101-19.

Kaplan EL. Thyroid and Parathyroids. In: Schwartz SI, Shier GT, Spencer FC, eds. Principles of Surgery. New York McGraw Hill Book Company. 1988;2:1613-85.

Sahin M, Gursoy A, Tutuncu NB, Guvener DN. Prevalence and prediction of malignancy in cytologically indeterminate thyroid nodules. Clin Endocrinol (Oxf). 2006;65(4):514-8.




How to Cite

Verma, N., Mohindroo, S., Azad, R., & Mohindroo, N. K. (2017). Macrocalcification in thyroid nodule. International Journal of Research in Medical Sciences, 5(7), 2960–2963.



Original Research Articles