DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20173079

Manuscript of risk factors for cancer cervix: an analysis of 1000 cases

Jita Parija, Janmejaya Mohapatra, Ashok Padhy

Abstract


Background: The global incidence of cervical cancer varies (5 lakhs new cases/year), highest in developing countries with >50% dying. Identification of risk factors is necessary to curb the disease.

Methods: In this study 1000 married women, attending A.H. Regional Cancer Centre Gynecological-Oncology OPD, from April 2016- March 2017 were randomly selected and subjected to Pap smear test of cervix and abnormal smears, biopsied. Histopathological report of HSIL/invasive carcinoma had HPV-DNA testing. Factors like menarche, coitarche, age at marriage, parity, contraception, smoking habit and socio-economic status were noted.

Results: In our study, HSIL was 4.2% and invasive cancer was 2.8%. Multiparity (>5) showed invasive cancer in 57.1% of cases. Menarche between 11-13 years had invasive cancer in 67.9%.  Incidence of invasive carcinoma in women married < 15 years was 42.9%. Barrier contraception showed protective role. In patients below poverty line, 78.6%, showed invasive cancer. Rural women showed a higher incidence of invasive carcinoma (67.9%). About 53.6% of invasive cancers were positive for HPV DNA.

Conclusions: Early menarche, early coitarche, early marriage, high parity, use of contraception other than barrier, low socioeconomic status, poor habitat and HPV infection, carried a high risk of developing cervical cancer. None of the patients in the study group smoked. HPV infection was the most important risk factor. Improvement of socioeconomic status, education and cervical cancer screening of the high-risk group can reduce cervical cancer mortality and morbidity significantly.


Keywords


Cervical cancer, HSIL, Risk factors, Screening

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References


Shanta V, Krishnamurthy S, Gajalakshmi CK. Epidemiology of cancer of the cervix: global and national perspective. J Indian Med Assoc. 2000; 98(2):49-52.

Juneja A, Sehgal A, Mitra AS, Pandey A. A summary on risk factors associated with cervical cancer. Indian J Cancer. 2003;40(1):15-22.

Jablonowska-Fudzzzinska D, Marszalek A. Tobbaco smoking as a cofactor for development of cervical cancer. Przegl Lek. 2015;72(3):103-5.

Makuza JD, Sanzimana SN, Ntaganire J. Prevalence of risk factors for cervical cancer and precancerous lesions in Rwanda. The Pan Afr Med J. 2015;22:26.

Safaeian M, Solomon D. Cervical cancer prevention: Science in education. J Ob Gynecol Clin North Am. 2007;34(4):793-9

Hinkula M., Pukkula E. A population based study on risk of cervical cancer and cervical intraepithelial neoplasia among grandmultiparous women in Finland. Br J Cancer. 2004;90(5):1025-29.

William M, Christopher MD, James E, Parker MD. Relation of cervical cancer to early marriage and childbearing. N Eng J Med. 19654;273:235-9.

Parikh S, Brennan P, Boffetta P. Meta‐analysis of social inequality and the risk of cervical cancer. Int J Canc. 2003;105(5):687-91.

Durowade KA, Osagbemi GK, Salaudeen AG, Musa OI, Akande TM, Babatunde OA, et al. Prevalence and risk factors of cervical cancer among women in an urban community of Kwara State, north central Nigeria. J preventive Med Hyg. 2012;53(4).

Sreedevi A, Javed R, Dinesh A. Epidemiology of cervical cancer with special focus on India. Int J Women's Health. 2015;7:405.

Nawal NM. Cervical cancer: a preventable death. Rev Obstet Gynecol, 2009;2(4):240-4.