Effect of probiotic supplement (kidilact) on prevention of acute diarrhea in children: a double-blind randomized clinical trial

Mehran Hesaraki

doi:10.18203/2320-6012.ijrms20172595

Authors

Mehran Hesaraki Department of Pediatrics, Medicine School, Zabol University of Medical Science, Zabol, Iran

DOI:

https://doi.org/10.18203/2320-6012.ijrms20172595

Keywords:

Acute viral diarrhea, Kidilact, ORS powder, Probiotic

Abstract

Background: Acute viral diarrhea is one of the most common diseases in children, which is associated with high risk of mortality. The present study aimed to determine the effect of Kidilact on the treatment of children with acute diarrhea.

Methods: This double-blind randomized clinical trial was conducted on 84 children aged 6-60 months with diarrhea, hospitalized in pediatric ward of Amir al-Mu'minin hospital of Zabol, Iran. The patients who met the inclusion criteria were included and assigned to the control and treatment groups (42 patients in each group). Data collection instruments included clinical examination of participants in terms of gender, medication, diet, stool test, weight, average heart rate, average respiratory rate, average body temperature, and average frequency of defecation Data was analyzed with descriptive and analytical tests (chi-square, Fisher's exact test, t-test, etc.) in SPSS-21.

Results: Body temperature, heart rate, and frequency of defecation significantly reduced in the intervention group after three days (p<0.05). In addition, weight gain presented an improving trend in the intervention group, but not significantly different from the control group (p<0.05).

Conclusions: Findings indicated that the use of Kidilact may be helpful in the treatment of acute viral diarrhea in children and play a key role in early recovery, reduction of disease severity, and improvement of vital signs in these patients.

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References

UNICEF, Organization WH; Clinical management of acute diarrhoea: WH; 2004.

Allen SJ, Martinez EG, Gregorio GV, Dans LF. Probiotics for treating acute infectious diarrhoea. Sao Paulo Med J. 2011;129(3):185.

Applegate JA, Walker CLF, Ambikapathi R, Black RE. Systematic review of probiotics for the treatment of community-acquired acute diarrhea in children. BMC Public Health. 2013;13(3):1.

Group FWW. Report of a joint FAO/WHO; expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Córdoba, Argentina: FAO/WHO; 2001.

Macfarlane GT, Cummings JH. Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health? West J Med. 1999;171(3):187.

Vanderhoof JA, Young RJ. Use of probiotics in childhood gastrointestinal disorders. J Pedia Gastroenterol Nutrit. 1998;27(3):323-32.

McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol. 2006;101(4):812-22.

Walker N, Fischer-Walker C, Bryce J, Bahl R, Cousens S. Standards for CHERG reviews of intervention effects on child survival. Int J Epidemiol. 2010;39(1):i21-31.

Dinleyici EC, Eren M, Ozen M, Yargic ZA, Vandenplas Y. Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea. Expert Opinion Onbiolo Therapy. 2012;12(4):395-410.

Saavedra JM, Bauman N, Perman J, Yolken R, Oung I. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. The lancet. 1994;344(8929):1046-9.

Szajewska H, Kotowska M, Mrukowicz JZ, Arma M, Mikolajczyk W. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pedia. 2001;138(3):361-5.

Mastretta E, Longo P, Laccisaglia A, BalboL, Russo R, Mazzaccara A, et al. Effect of Lactobacillus GG and breast-feeding in the prevention of rotavirus nosocomial infection. J Pedi Gastroenterol Nutrition. 2002;35(4):527-31.

Szajewska H, Setty M, Mrukowicz J, Guandalini S. Probiotics in gastrointestinal diseases in children: hard and not-so-hard evidence of efficacy. J Pedia Gastroenterol Nutrition. 2006;42(5):454-75.

Agustina R, Kok FJ, van de Rest O, Fahmida U, Firmansyah A, Lukito W, et al. Randomized trial of probiotics and calcium on diarrhea and respiratory tract infections in Indonesian children. Pedia. 2012;129(5):e1155-64.

Huang YF, Liu PY, Chen YY, Nong BR, Huang IF, Hsieh KS, et al. Three-combination probiotics therapy in children with salmonella and rotavirus gastroenteritis. J Clin Gastroenterol. 2014;48(1):37-42.

Erdoğan Ö, Tanyeri B, Torun E, Gönüllü E, Arslan H, Erenberk U, et al. The comparison of the efficacy of two different probiotics in rotavirus gastroenteritis in children. J Tropical Med. 2012;2012.

Sazawal S, Dhingra U, Sarkar A, Dhingra P, Deb S, Marwah D, et al. Efficacy of milk fortified with a probiotic Bifidobacterium lactis (DR-10) and prebiotic galacto-oligosaccharides in prevention of morbidity and on nutritional status. Asia Pacific J Clin Nutrition. 2004;13.

Guandalini S. Probiotics for children with diarrhea: an update. J Clin Gastroenterol. 2008;42:S53-7.

Szajewska H, Skorka A, Ruszczyński M, Gieruszczak‐Białek D. Meta‐analysis: Lactobacillus GG for treating acute diarrhoea in children. Aliment Pharmacol Therap. 2007;25(8):871-81.