The study of serum c-reactive protein and its diagnostic importance in reducing the rate of negative appendectomy

Authors

  • Bandana Kumari Department of Biochemistry, Vardhhman Institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India
  • Pawan Kumar Department of CT Scan and Ultrasonography, Dev Imaging and Diagnostic Centre, Patna, Bihar, India
  • Neha Chaudhary Department of Community Medicine, Government Medical College and Rajindra Hospital, Patiala, Chandigarh, India
  • Anil Kumar Department of General Surgery, All India Institute of Medical Sciences, Patna, Bihar, India
  • Achal Narain Roy Department of Biochemistry, Patna Medical College and Hospital, Patna, Bihar, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20172617

Keywords:

Acute appendicitis, Appendectomy, C-reactive protein

Abstract

Background: Introduction-Acute appendicitis is the most common abdominal surgical emergency and appendectomy is one of the most frequently performed abdominal operation but the diagnosis of acute appendicitis remains an enigmatic challenge, plagued by high rate of negative exploration. The objective of this study was to assess the accuracy of CRP over TLC in the diagnosis of acute appendicitis.

Methods: Total 200 patients who had been diagnosed as a case of acute appendicitis based on WBC count and clinical diagnosis and were planned for appendectomy were selected for purposive sampling. Serum CRP was estimated in these patients before operation but was not considered in decision making process of appendectomy. All 200 removed appendixes were sent for histopathological examination.

Results: Result-Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of serum CRP were much greater than WBC count. Mean and standard deviation of serum CRP was 41.92±26.28 with p=<0.0001 which is highly significant.

Conclusions: Conclusion-CRP should be added along with clinical diagnosis and other laboratory test in diagnosis of acute appendicitis to reduce the rate of negative appendectomy.

Author Biographies

Bandana Kumari, Department of Biochemistry, Vardhhman Institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India

DEPARTMENT OF BIOCHEMISTRY, ASSISTANT PROFESSOR.

Pawan Kumar, Department of CT Scan and Ultrasonography, Dev Imaging and Diagnostic Centre, Patna, Bihar, India

DEPARTMENT OF CT SCAN AND ULTRASONOGRAPHY, SENIOR CONSULTANT RADIOLOGIST.

Neha Chaudhary, Department of Community Medicine, Government Medical College and Rajindra Hospital, Patiala, Chandigarh, India

DEPARTMENT OF COMMUNITY MEDICINE, POST GRADUATE RESIDENT.

Anil Kumar, Department of General Surgery, All India Institute of Medical Sciences, Patna, Bihar, India

DEPARTMENT OF SURGERY, ASSISTANT PROFESSOR.

Achal Narain Roy, Department of Biochemistry, Patna Medical College and Hospital, Patna, Bihar, India

DEPARTMENT OF BIOCHEMISTRY, PROFESSOR AND H.O.D.

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Published

2017-06-24

How to Cite

Kumari, B., Kumar, P., Chaudhary, N., Kumar, A., & Roy, A. N. (2017). The study of serum c-reactive protein and its diagnostic importance in reducing the rate of negative appendectomy. International Journal of Research in Medical Sciences, 5(7), 2841–2844. https://doi.org/10.18203/2320-6012.ijrms20172617

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Original Research Articles