DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20173968

Serum BUN and creatinine estimation in patients of overt hypothyroidism: a case control study

Bandana Kumari, Pawan Kumar, Jiut R. Keshari, Arun Kumar, Sangeeta Pankaj, Radha K. P. Chaudhary

Abstract


Background: Hypothyroidism or underactive thyroid or low thyroid is a common endocrine disorder characterized by low serum T3 (triiodothyronine), T4 (thyroxine) and raised TSH (thyroid stimulating hormone). Thyroid hormones are involved in renal development and hemodynamic, kidney structure and GFR (glomerular filtration rate). Aim of this study was to see the alteration of basic renal markers in patients of hypothyroidism.

Methods: A total of seventy subjects were included in the study. Thirty-five were patients of hypothyroidism and thirty-five were age and sex matched normal controls. Serum T3, T4, TSH, creatinine and BUN (blood urea nitrogen) were estimated in both groups.

Results: Serum T3, T4 were significantly decreased and TSH was significantly raised among cases as compared to controls. Mean value of serum creatinine and BUN were within normal range in both the groups but these values were significantly raised among cases as compared to controls with p value 0.02 and 0.003 respectively. Also, there was positive correlation of TSH with BUN and creatinine among cases.


Keywords


BUN (blood urea nitrogen), Creatinine, GFR, Hypothyroidism

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References


Irizarry L. Thyroid hormone toxicity. Medscape. WedMD LLC. Retrieved. 2014 May;2.

Edward C Kendall. American Society for Biochemistry and Molecular Biology. Retrieved 2011-07-04. Available at http://www.asbmb.org/uploadedfiles/AboutUs/ASBMB_History/Past_Presidents/1920s/1926Kendall.html.

Maia AL, Goemann IM, Meyer EL, Wajner SM. Type 1 iodothyronine deiodinase in human physiology and disease deiodinases: the balance of thyroid hormone. J Endocrinol. 2011;209(3):283-97.

Cheng SY, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocrine Reviews. 2010;31(2):139-70.

Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults. Thyroid. 2012;22(12):1200-35.

Chakera AJ, Pearce SH, Vaidya B. Treatment for primary hypothyroidism: current approaches and future possibilities. Drug Design Development Therapy. 2012;6:1-11.

Robert FD, Wians FH. Endocrine and metabolic disorders clinical lab testing manual, 4th ed. Boca Raton. 2009:10.

Carle A, Laurberg P, Pedersen IB, Knudsen N, Perrild H, Ovesen L, et al. Epidemiology of subtypes of hypothyroidism in Denmark. Eu J Endocrinol. 2006;154:21-8.

Klubo-Gwiezdzinska J, Wartofsky L. Thyroid emergencies. Medical Clinics North America. 2012;96(2):385-403.

Mamatha BV, Rakshitha MN, Kashinath RT, Thomas LR. Evaluation of serum urea and creatinine levels in subclinical hypothyroidism-a case control study. Medica Innovatica. 2016;5(2).

Basu G, Mohapatra A. Interactions between thyroid disorders and kidney disease. Indian J Endocrinol Metab. 2012;16(2):204-13.

Vargas F, Moreno JM, Rodriguez-Gomez I, Wangensteen R, Osuna A, Alvarez-Guerra M. Vascular and renal function in experimental thyroid disorders. Eur J Endocrinol. 2006;154:197-212.

Montenegro J, Gonzalez O, Saracho R, Aguirre R, Martinez I. Changes in renal function in primary hypothyroidism. Am J Kidney Dis. 1996;27:195-8.

Asmah BJ, Wan Nazaimoon WM, Norazmi K, Tan TT, Khalid BA. Plasma renin and aldosterone in thyroid diseases. Horm Metab Res. 1997;29:580-3.

Kimmel M, Braun N, Alscher M. Influence of thyroid function on different kidney function tests. Kidney Blood Press Res. 2012;35:9-17.

Kaptein EM. The kidneys and the electrolyte metabolism in hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner and Ingbar’s The Thyroid. 9th ed, Philadelphia, Pa: Lippincott Williams and Wilkins; 2005:792-3.

Balldin J, Berqgren U, Svennerholm L. Reduced glomerular filtration rate in a lithium-treated bipolar patient with primary hypothyroidism-reversal by levothyroxine. Clin Nephrol. 1988;29(3):160-1.

Sidhu GK, Malek RR, Khubchandani A, Mansuri SH, Patel MS, Oza RH. A study of serum urea, creatinine and uric acid levels in hypothyroid patients. Int J Res Med. 2016;5(2);115-8.

Kaur V, Singh K, Verma M. Changes in biochemical markers of renal function in subclinical and overt hypothyroidism. Int J Bioassays. 2015;4(04):3799-802.

Rashead QA, Hamid DM. The effect of thyroid hormone on some biochemical factors of kidney. Int J Advanced Res. 2015;3(7):290-7.