Prevalence of transfusion transmitted infections amongst multiple blood transfused patients of β-thalassemia major in a tertiary care hospital
DOI:
https://doi.org/10.18203/2320-6012.ijrms20164545Keywords:
Thalassemia, Transfusion transmitted infection, HBV, HCV, HIVAbstract
Background: The β-thalassemias are the most common autosomal recessive inherited hemoglobin disorder in the Indian subcontinent, with an uneven distribution among different endogenous populations. Present study was planned to estimate the prevalence of transfusion transmitted viral diseases in multiple transfused patients of β-thalassemia and factors affecting it.
Methods: It was a Prospective observational study carried out at Thalassemia day care center of tertiary health care institute.
Results: 211 patients were enrolled in the study. 151 were males and 60 females. Maximum numbers of children were in age group of 6- 10 years. 75 (35.5%) patients with HCV (Hepatitis C Virus) and 5 (2.36%) patients with Hepatitis B virus (HBV) infection were found at the end of study. No new HIV (Human Immunodeficiency Virus) infection was detected. There was significant association between prevalence of transfusion transmitted infections (TTI) with number of transfusions but no significant association detected with age, sex and blood group of the patients
Conclusions: Thalassemia is a chronic transfusion dependent disease complicated by the effects of iron overload on various organs leading to increased morbidity and mortality. The risk of transmission of TTI in thalassemia increases with time as number of transfusions increase. Use of advanced technology in blood screening, voluntary donations, donor selection, asepsis during blood transfusion should be used to curtail the transmission.References
Agarwal MB, Mehta BC. Genotype analysis of symptomatic thalassemia syndrome. J Postgrd. Med. 1982;28:1-3.
Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood. 1997;89:739-61.
Chuodhury N, Saraswat S, Naveed M. Serological monitoring of thalassemia major patients for transfusion associated viral infections. Indian J Med Res. 1998;107:263-8.
Lee WS, Chan LL. Risk of seroconversion of hepatitis B, hepatitis C and HIV in children with multitransfused thalassemia major. J Paediatr Child Health. 2005;41:265-8.
Brecher ME, Butch SH, Calhoun AR, Fiebig EW, Goodnough LT, Hahn L et al. In: Technical manual of the American Association of Blood Banks. 283-336.
Fongsatitkul L, Bannawat U, Sanguansermsri T, Kulapongs P, Unexpected red cell antibodies in thalassemic children. Birth Defects Orig Artic Ser. 1998;23:291-3.
Choudhury N, Phadke S. Transfusion transmitted diseases. Indian J Pediatr. 2001;68:951-8.
Choudhury N, Naik S, Ramesh V, High frequency of transfusion transmitted viral infection markers in thalassemia major patients. Indian J Hematol Blood Transfus. 1995;13:115-8.
Singh H, Pradhan M, Singh RL, Phadke S, Naik SR, Aggarwal R, et al. High frequency of hepatitis B virus infection in patients with beta thalassemia receiving multiple transfusions. Vox Sang. 2003;84:292.
Karimi M, Ghvanini AA. Seroprevalence of hepatitis B, hepatitis C, and human immunodeficiency virus antibodies among multitransfused thalassemic children in Shiraz, Iran. J Paediatr Child Health. 2001;37:564-6.
Abrol P, Lal H. Transfusion transmitted bacterial, viral, protozoal infections, blood transfusion in clinical practice. Available at: www.intechopen.com.
Bhavasar H, Patel K, Vagad M, Madan M, Pandey A. Prevalence of HIV, Hepatitis B and Hepatitis C infection in Thalassemia major patients in tertiary care hospital, Gujarat. NJIRM. 2011;2:47-50.
Grewal A, Sobti PC. Prevalence hepatitis B and C in thalassemic patients in Punjab. Rivista italiana di medicina dell adolscenz. 2007;5.
El-Faramawy, El-Rashidy O, Tawfik PH, Hussein GH. Transfusion Transmitted Hepatitis: Where Do We Stand Now? A One Center Study in Upper Egypt. Hepat Mon. 2012;12:286-91.
Jain R, Perkins J, Johnson Susan T, Desai P, Khatri A, U Chudgar and N.Choudhury. A prospective study for prevalence of transfusion transmitted infection in multiple transfused thalassemia major patients. Asian J Transfus Sci. 2012;6:151-4.
Mirmomen S, Alavian SM, Hajarizadeh B. Epidemiology of HBV, HCV and HIV in patients with beta thalassemia in Iran: a multicenter study. Archives of Iranian Medicine. 2006;9,319-23.
Mansour AK, Aly RM, Abdelrazek SY, Elghannam DM, Abdelaziz SM, Shahine DA, et al. Prevalence of HBV and HCV infection among multi-transfused Egyptian thalassemic patients. Hematol Oncol Stem Cell Ther. 2012;5:54-9.
Lee WS, Teh CM, Chan LL. Risks of seroconversion of hepatitis B, hepatitis C and human immunodeficiency viruses in children with multitransfused thalassaemia major. J Paediatr Child Health. 2005;41:265-8.
Katabuka M, Mafuta ME, Ngoma AM, Beya PM , Yuma S, Aketi L et al. Prevalence and Risk Factors for Hepatitis C Virus, Hepatitis B Virus, and Human Immunodeficiency Virus in Transfused Children in Kinshasa. Indian J Pediatr. 2013;8:659-62.
Ansari SH, Shamsi TS, Khan MT, Perveen K, Farzana T, Erum S, et al. Seropositivity of hepatitis C, hepatitis B and HIV in chronically transfused β-thalassaemia major patients. J Coll Physicians Surg Pak. 2012;22:610-1.
Mollah AH, Nahar N, Siddique MA, Anwar KS, Hassan T, Azam MG. Common transfusion-transmitted infectious agents among thalassaemic children in Bangladesh. J Health Popul Nutr. 2003;21:67-71.
Vidija PJ, Vanchani JH, Sheikh SS, Santwani PM. Blood transfusion transmitted infections in multiple blood transfused patients of β-thalassemia. Ind J Hematol blood Transfus. 2011;27:65-9.
Ocak S, Kaya H, Cetin M, Ozturk GM. Seroprevalence of hepatitis B and hepatitis C in patients with thalassemia and sickle cell anemia. Arch Med Res. 2006;37:895-8.
