Levobupivacaine versus racemic bupivacaine: a comparative study on spinal anaesthesia in lower limb surgeries
DOI:
https://doi.org/10.18203/2320-6012.ijrms20174558Keywords:
Bupivacaine, Intrathecal, Lower Limb, Racemic, SurgeriesAbstract
Background: This study aims to compare the anaesthetic potency of intrathecally administered levobupivacaine with racemic bupivacaine in lower limb surgeries.
Methods: 60 adult cases ranging in age from 18 to 60 years with ASA Grade I and II, presenting for elective lower limb surgery were randomly allocated into two groups containing 30 cases each. Cases in Group L received 3ml of 0.5% levobupivacaine and those in Group R received 3ml of 0.5% levobupivacaine.
Results: Cases in both groups showed similarity and no statistically significant differences were observed. Cardiovascular parameters were stable and similar between both groups.
Conclusions: Levobupivacaine and racemic bupivacaine show equally effective potencies for spinal anaesthesia in lower limb surgeries.
References
Casati A. Intrathecal Anaesthesia. Curr Opin Anaes. 2002;15:543-1.
Rowney DA, Doyle E. Epidural and subarachnoid blockade in children. Anaesthesia. 1998;53:980-1001.
Broadman LM, Hannallah RS. Experience with 1154 consecutive cases without complications. Anaesth Anal. 1987;66:848-54.
Aberg G. Toxicological and local anaesthetic effect effects of two local anaesthetic compounds. Acat Pharm Toxicol Scand. 1972;16:22-8.
Gristwood RW. Levobupivacaine: A new safer long acting local anaesthetic agent. Anaesth Analg. 1999;8:861-78.
Hansen TG, Hennerberg SW, Lund J. Caudal bupivacaine supplemented with caudal or intravenous clonidine in children undergoing hypospadias repair. Br J Anaesth. 2004;92:223-7.
Kumar P, Rudra R, Pan AA, Asharia A. Comparison among midazolam, Ketamine and neostigmine co-administered with bupivacaine. Anaesth Analg. 2005;101:69-73.
Rosa H. Isobaric Bupivacaine versus hypobaric bupivacaine for subarachnoid anaesthesia in patients of hip surgery. Anaesth Analg. 2014;14:97.
Monica D. Spinal anaesthesia for knee arthroscopy. Biomed Res. 2014;34(9):90-2.
Foxall G. Levobupivacaine induced seizures and cardiovascular collapse. Anaesthesia. 2007;62:516-8.
