Common thrombophilia markers in young patients with primary arterial and venous thrombosis

Authors

  • Monika Gupta Department of Pathology, Pt BDS, PGIMS, UHS, Rohtak
  • Megha Kathuria Department of Pathology, Pt BDS, PGIMS, UHS, Rohtak
  • Nisha Marwah Department of Pathology, Pt BDS, PGIMS, UHS, Rohtak
  • Rajeev Sen Department of Pathology, Pt BDS, PGIMS, UHS, Rohtak

DOI:

https://doi.org/10.18203/2320-6012.ijrms20163320

Keywords:

Thrombosis, Protein C, Protein S, Antithrombin III

Abstract

Background: The pathogenesis of vascular thrombotic event involves an interaction of multiple genetic and environmental factors. Genetic factors include activated protein C resistance, deficiency of natural anticoagulants protein C, protein S, factor V and antithrombin III while acquired cause include presence of antiphospholipid antibody. This study was carried out to establish the role of basic panel of thrombophilia in diagnosing the patients with primary thrombophilia.

Methods: A total of 121 consecutive patients with history suggestive of arterial or venous thrombosis were included. History of risk factors including smoking, hypertension, hyperlipidemia, diabetes mellitus and family history of thrombosis were elicited. The initial tests included CBC, PT, APTT, LFT, blood sugar and lipid profile. Functional assay on thrombophilia markers were performed by means of clotting based method.

Results: A total of 121 patients were studied, out of which 63 were males and 58 females. The mean age range was 15-40 years. No abnormality was detected in 75 samples, while 46 samples (38%) were positive for one or more thrombophilia markers, of which 6 had more than one thrombophilia marker. Abnormality of a single thrombophilia factor was found in 40 patients, in which two patients were also positive for lupus anticoagulant.

Conclusions: An association was found between low levels of protein C, protein S and factor V and a thrombotic event. Screening of these patients using a panel of thromophilia markers can provide valuable information in primary diagnosis of inherited deficiency even in the absence of high end molecular/mutational studies.

References

Kumar DR, Hanlin E, Glurich I, Mazza JJ, Yale SH. Virchow’s contribution to the understanding of thrombosis and cellular biology. Clin Med Res. 2010;8(3-4):168-72.

Caprini JA, Goldshteyn S, Glase CJ, Hathaway K. Thrombophilia testing in patients with venous thrombosis. Eur J Vascular and Endovascular Surgery. 2005;30(5):550-5.

Soare AM, Popa C. Deficiencies of Proteins C, S and Antithrombin and Activated Protein C Resistance– Their Involvement in the Occurrence of Arterial Thromboses. J Med Life. 2010;3(4):412-5.

Mishra MN, Bedi VS. Prevalence of common thrombophilia markers and risk factors in indian patients with primary venous thrombosis. Sao Paulo Med J. 2010;128(5):263-7.

Mishra MN, Kalra R, Rohatgi S. Clinical profile, common thrombophilia markers and risk factors in 85 young indian patients with arterial thrombosis. Sao Paulo Med J. 2013;131(6):384-8.

Wolf M, Boyer-Neumann C, Martinoli JL, Leroy-Matheron C, Amiral J, Meyer D, et al. A new functional assay for human protein S activity using activated factor V as substrate. Thromb Haemost. 1989;62(4):1144-5.

Herrmann FH, Salazar-Sanchez L, Schröder W. Prevalence of molecular risk factors FV Leiden, FV HR2, FII 20210G>A and MTHFR677C>T in different populations and ethnic groups of Germany, Costa Rica and India. IJHG. 2001;1(1):33-9.

Bhattacharyya M, Kannan M, Chaudhry VP, Saxena R. Venous thrombosis: prevalence of prothrombotic defects in north Indian population. Indian J Pathol Microbiol. 2003;46(4):621-4.

Saxena R, Mohanty S, Srivastava A, Choudhry VP, Kotwal J. Pathogenetic factors underlying juvenile deep vein thrombosis (DVT) in Indians. Eur J Haematol. 1999;63(1):26-8.

Khare A, Ghosh K, Shetty S, Kulkarni B, Mohanty D. Combination of thrombophilia markers in acute myocardial infarction of the young. Indian J Med Sci. 2004;58(9):381-8.

Anderson FA, Spencer FA. Risk Factors for Venous Thromboembolism. Circulation. 2003;107:I9-16.

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Published

2016-12-19

How to Cite

Gupta, M., Kathuria, M., Marwah, N., & Sen, R. (2016). Common thrombophilia markers in young patients with primary arterial and venous thrombosis. International Journal of Research in Medical Sciences, 4(10), 4516–4519. https://doi.org/10.18203/2320-6012.ijrms20163320

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Original Research Articles