Frontonasal dysplasia- a rare case report

Reena Sharma, Poojan Dogra, Kapil Malhotra, Vivek Kaushal


Frontonasal dysplasia (FND) is a rare malformative complex affecting the frontal portion of the face, the eyes and the nose; it may occur singly or associated with other clinical signs. We report here a rare case of a full-term male baby who presented with features of FND. There was no history of consanguinity, no positive family history. Antenatal ultrasonography was normal. Though this baby did not survive because the defects were not compatible for the survival. But the developing nations still have handicap in the management of such cases in term of fiancés, surgical correction of such major defects, education and social support in these patients. 


Frontonasal dysplasia, FND, Facial cleft, Neonate

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Lenyoun EH, Lampert JA, Xipoleas GD, Taub PJ. Salvage of calvarial bone graft using acellular dermal matrix in nasal reconstruction and secondary rhinoplasty for frontonasal dysplasia. J Craniofac Surg. 2011;22(4):1378-82.

Wu E, Vargevik K, Slavotinek AM. Subtypes of frontonasal dysplasia are useful in determining clinical prognosis. Am J Med Genet A. 2007;143A(24):3069-78.

Fryburg JS, Persing JA, Lin KY. Frontonasal dysplasia in two successive generations. Am J Med Genet. 1993;46(6):712-4.

Vaccarella F, Pini Prato A, Fasciolo A, Pisano M, Carlini C, Seymandi PL. Phenotypic variability of Pai syndrome: report of two patients and review of the literature. Int J Oral Maxillofacial Surg. 2008;37(11):1059-64.

Fearon JA. Rare craniofacial clefts: a surgical classification. J Craniofacial Surg. 2008;19(1):110-2.

Verloes A, Gillerot Y, Walczak E, Van Maldergem L, Koulischer L. Acromelic frontonasal dysplasia: further delineation of a subtype with brain malformation and polydactyly (Toriello syndrome). Am J Med Genet. 1992;42(2):180-3.

Bello M, Garandawa H, Mustapha Z, Isa A, Tahir C, Ngamdu YB, et al. Frontonasal dysplasia Sequence: a case report. Nigerian J Paediatr. 2014;41(2):151-3.

Median Facial Cleft Syndrome. Available at

Taybi H. Radiology of syndromes and metabolic disorders. Pediatric Surgery. 2nd ed. Chicago, IL: Year Book Medical; 1983:235.

Fox JW, Golden GT, Edgerton MT. Frontonasal dysplasia with alar clefts in two sisters. Genetic considerations and surgical correction. Plast Reconstr Surg. 1976;57:553-6.