Prevalence of thyroid dysfunction in type 2 diabetes mellitus: a case control study

Ajaz Ahmad Telwani, Zahid Hussain Wani, Younis Ashraf, Aejaz Ahmad Shah


Background: Diabetes mellitus and thyroid disorders are the most common endocrine disorders worldwide. Various studies have found that diabetes and thyroid disorders mutually influence each other and both disorders tend to coexist. So, we conducted a study to find out the prevalence of thyroid disorders in patients of type 2 diabetes mellitus.

Methods: This study was conducted on 100 diabetic patients and 100 controls. All the participants were evaluated for thyroid dysfunctions by testing thyroid profile. The correlation of prevalence of thyroid disorder with age distribution, gender distribution, BMI, duration of diabetes and HbA1C was then done.

Results: The prevalence of thyroid dysfunctions were high in diabetic patients compared to controls (29% versus 9%, P value <0.001). Most common thyroid disorder in diabetic patients was subclinical hypothyroidism (16%) while least common was hyperthyroidism (1%). The levels of serum T3 and T4 were significantly low while serum TSH levels were significantly high in diabetic group compared to control group. Prevalence of thyroid disorders in diabetics were significantly more in patients with age ≥ 50 years, more in females, more in patients with BMI ≥ 30 and more in patients with duration of diabetes ≥ 5 years. The association of prevalence of thyroid disorders with HBA1C was not significant.

Conclusions:Current study showed high prevalence of thyroid dysfunctions in diabetic patients. We conclude that screening for thyroid dysfunction among patients with diabetes mellitus should be routinely performed, so as to recognize these dysfunctions early. 



Diabetes mellitus, Thyroid Dysfunction, T3, T4, TSH

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Faghilimnai S, Hashemipour M, Kelishadi B. Lipid profile of children with type 1 diabetes compared to controls. ARYA J. 2006;2(1):36-8.

Sachin B, Mahesh M, Sachin S, Vaishali G. Evaluation of thyroid hormones in patients with type II diabetes mellitus. J Med Educ Res. 2013;3(2):33-9.

American diabetes association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2010;33:562-9.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes. Diabetes Care. 2004;27:1047-53.

Zimmat P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2000;414(6865):782-7.

Gray RS, Irvine WJ, Clarke BF. Screening for thyroid dysfunction in diabetics. Br Med J. 1979;2(6202):1439.

Perros P, McCrimmon RJ, Shaw G, Frier BM. Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabet Med. 1995;12 (7):622-7.

Smithson MJ. Screening for thyroid dysfunction in a community population of diabetic patients. Diabet Med. 1998;15(2):148-50.

Celani MF, Bonati ME, Stucci N. Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with Type 2 diabetes mellitus. Diabete Res. 1994;27(1):15-25.

Udoing CEJA, Udoh E, Etukudoh ME. Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria, Indian J Clin Biochem. 2007;22:74-8.

Sugure DD, Mc Evoy M, Drury MI. Thyroid disease in diabetics. Postgrad Med J. 1999;91(1):680-4.

Shah SN. Thyroid disease in diabetes mellitus. J Assoc Physicians India. 1984;32(12):1057-9.

Mukherjee S, Datta S, Datta P, Mukherjee AK, Maisnam I. A study of prevalence of primary hypothyroidism in recently diagnosed type 2 diabetes mellitus in a tertiary care hospital. Int J Sci Rep. 2015;1(2):105-12.

Ghazali SM, Abbiyesuku FM. Thyroid dysfunction in type 2 diabetics seen at the University college hospital, Ibadan, Nigeria. Nig J Physiol Sci. 2010;25(2):173-9.

Singh G, Gupta V, Sharma AK, Gupta N. Evaluation of thyroid dysfunction among type-2 diabetic population. Advances Biores. 2011;2(2):3-9.

Demitrost L, Ranabir S. Thyroid dysfunction in type 2 diabetes mellitus: a retrospective study. Indian J Endocrinol Metab. 2012;16(2):S334-5.

Diez JJ, Sanchez P, Iglesias P. Prevalence of thyroid dysfunction in patients with type 2 diabetes. Exp Clin Endicrinol Diabetes. 2011;119(4):201-7.

Radaideh AR, Mo MK, Amari FL, Bateiha AE, El-Khateeb MP, Naser PA, et al. Thyroid dysfunction in patients with type 2 diabetes mellitus in Jordan. Saudi Med J. 2004;25(8):1046-50.

Papazafiropoulou A, Sotiropoulos A, Kokolaki A, Kardara M, Stamataki P, Pappas S. Prevalence of thyroid dysfunction among Greek type 2 diabetic patients attending an outpatient clinic. J Clin Med Res. 2010;2(2):75-8.

Nobre E, Jorge Z, Pratas S, Silva C, Castro J. Profile of the thyroid function in a population with type-2 diabetes mellitus. Endocrine Abstracts. 2008;3:298.

Babu K, Kakar A, Byotra SP. Prevalence of thyroid disorder in type II diabetes mellitus patients. J Assoc Phys Ind. 2001;49:43.

Michalek AM, Mahoney MC, Calebaugh D. Hypothyroidism and diabetes mellitus in an American Indian population. J Family Practice. 2000;49(7):53-5.

Whitehead C, Lunt H, Pearson JF, Cawood TJ. Is screening for hypothyroidism in the diabetes clinic effective? Practical Diabetes. 2010;27(3):113-7.

Feely J, Isles TE. Screening for thyroid dysfunction in diabetics. Br Med J. 1979;1:1678.

Vondra K, Vrbikova J, Dvorakova K. Thyroid gland diseases in adult patients with diabetes mellitus. Minerva Endocrinol. 2005;30:217-36.

Moulik PK, Nethaji C, K haleeli AA. Thyroid dysfunction in diabetes: can we justify routine screening? Endocrine Abstracts. 2002;3:292.

Johnson JL. Diabetes and thyroid disease: a likely combination. Diabetes Spectrum. 2002;15:140-2.

Pimenta WP, Mazeto GM,

Callegaro CF, Shibata SA, Marins LV, Yamashita S, et al. Thyroid disorders in diabetic patients. Arq Bras Endocrinol Metab. 2005;49(2):234-40.

Proces S, Delgrange E, Vander BTV, Jamart J, Donckier JE. Minor alterations in thyroid function tests associated with diabetes mellitus and obesity in outpatients without known thyroid illness. Acta Clin Belg. 2001;56(2):86-90.

Schlienger JL, Anceau A, Chabrier G, North ML, Stephan F. Effect of diabetic control on the level of circulating thyroid hormones. Diabetologia. 1982;22:486-8.

Bazrafshan HR, Ramezani A, Salehi A, Shir AAA, Mohammadian S, Faraj EM, et al. Thyroid dysfunction and its relationship with diabetes mellitus (NIDDM). J Gorgan Univ Med Sci. 2000;2(5):5-11.

Ardekani MA, Rashidi M, Shojaoddiny A. Effect of thyroid dysfunction on metabolic response in type 2 diabetic patients. Iranian J Diabetes Obesity. 2010;2(1):20-6.