Email this article Impact of standard nutrition therapy and medical nutrition therapy on the immune status i.e. complement C3 and C4 in severely acute malnourished children
Abstract
Background: The objective of this study is to scientifically study and assess the levels of C3 and C4 in SAM children pre-and post-supplementation with MNT and SNT.
Methods: In this comparative study we have analyzed C3 in 40 severely acute malnourished children pre and post medical nutrition therapy (MNT) and 35 severely acute malnourished children pre and post standard nutrition therapy (SNT) in the age group of 1 month to 3 years and C4 in 40 severely acute malnourished children pre and post medical nutrition therapy (MNT) and 35 severely acute malnourished children pre and post standard nutrition therapy (SNT) in the age group of 1 month to 3 years at LTM medical college and general hospital. C3 and C4 were analyzed by immunoturbidimetric assay method on RX Daytona analyzer.
Results: The level of C3 was significantly low prior to the supplementation which increased after nutrition therapy, in both the groups. However, C4 levels decreased in both the groups. This decreased was found to be significant. The decrease of C4 in children supplemented with MNT was greater than those supplemented with SNT children.
Conclusions: The values of C3 which increased after supplementation and the decreased values of C4 after supplementation were more significant in the MNT group this confirms MNT is a better therapy for curing malnutrition than that of the SNT.
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Ghai OP. New development in pediatric research: immunology and the humoral immune response. 1977;5:545-7.
WHO, Management of severely malnutrition. A manual for physicians and other senior health workers. Geneva: World Health Organization 1999. Available at http://apps.who.int/iris/bitstream/10665/41999/1/a57361.pdf.
Cunningham-Rundles S, McNeely D, Ananworanich JM. Immune response in malnutrition. In: Stiehm ER, Ochs HD, Winkelstein JA, editors. Immunologic Disorders in Infants and Children. 5. Philadelphia, PA: Elsevier Saunders; 2004:761-784.
Sahu A, Lambris JD. Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunological Reviews. 2001;180(1):35-48.
Yang Y, Chung EK, Zhou B, Blanchong CA, Yu CY, Fust G, et al. Diversity in intrinsic strengths of the human complement system: serum C4 protein concentrations correlate with C4 gene size and polygenic variations, hemolytic activities, and body mass index. J Immunol. 2003;171(5):2734-45.
Alper CA, Rosen FS. Clinical applications of complement assays. Advances Internal Med. 1975;20:61-88.
Whicher, J. Complement Component C3. In: Richie RF, Novolotskaia, O, eds. Serum proteins in Clinical Medicine” Scarborough: Foundation for Blood Research. 1996:1-7.
Labor T. Clinical Laboratory Diagnostics. 1st edition. Use and Assessment of Clinical Laboratory Results. 1998:696.
McMurray DN, Watson RR, Reyes MA. Effect of renutrition on humoral and cell-mediated immunity in severely malnourished children. Am J Clinical Nutrition. 1981;34(10):2117-26.
Rikimaru T, Taniguchi K, Yartey JE, Kennedy DO, Nkrumah FK. Humoral and cell-mediated immunity in malnourished children in Ghana. European J Clin Nutrition. 1998;52(5):344-50.
Rhoades RA, Pflanzer RG. Human Physiology. 4th edition. Thomson Learning; 2002;584.
Maverakis E, Kim K, Shimoda M, Gershwin ME, Patel F, Wilken R, et al. Glycans in the immune system and the Altered Glycan Theory of Autoimmunity: a critical review. J Autoimmunity. 2015;57:1-3.
Matsuyama W, Nakagawa M, Takashima H, Muranaga F, Sano Y, Osame M. "Molecular analysis of hereditary deficiency of the third component of complement (C3) in two sisters". Internal Medicine. 2001;40(12):1254-8.
Lachmann P. Genetics of the complement system. Journal Medical Genetics. 1995;12(4):372-7.
Goldsby R, Kind T, Osborne B. “The Complement System” in Kuby Immunology. 4th edition; 2000:329-473.
