DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20174138

A comparative study of in clinico-pathological profile in dengue shock syndrome versus other types children's at tertiary health care center

Bhavesh Shah, Deepa Sachin Phirke

Abstract


Background: Dengue a mosquito borne arboviral disease is caused by one of the serotypes of dengue virus (DEN-1, DEN-2, Den-3, DEN-4) belonging to the family Flaviviridae. The objective of this study was to study clinco-pathological profile of Dengue shock syndrome versus Other types children's at tertiary health care center.

Methods: This was Cross sectional observational study was conducted in a tertiary care hospital in the Department of Pediatrics after obtaining approval from the institutional Ethical Committee. The study was carried out over a period of one & half years from January 2015 to June 2016 Statistical analysis done by Chi-square, ANOVA, Paired t test SPSS version 22 (IBM SPSS Statistics, Somers NY, USA) was used to analyze data.

Results: Mean age of patients were 8.08±2.72 years, majority of cases were females (51.9%) and 48.1% were males, the clinical features like hepatomegaly, Ascites Pleural Effusion significantly present in DSS (P<0.001). In the study, there was no significant difference in symptoms and severity of dengue fever except for convulsion Thrombocytopenia (platelet<1lakh/cmm) was observed in 74% of cases, leucopenia (total leukocyte count <4000/cmm) was observed in 56% of cases, haemocrit more than 40 was observed in 21.27% cases. Dengue shock syndrome had acute kidney injury, CCF and encephalopathy. This observation of complications between dengue severity was statistically significant. There was significant difference in haematocrit values between three diagnoses of dengue fever from day 1 till day 4. Initially higher haematocrit was observed in Dengue shock syndrome, later goes on decreasing.

Conclusions: It can be concluded from our study that significantly dengue shock syndrome had acute kidney injury, CCF and encephalopathy. There was significant difference in hematocrit values between three diagnoses of dengue fever from day 1 till day 4. Initially higher hematocrit was observed in dengue shock syndrome.


Keywords


Complication of dengue fever, Dengue hemorrhagic fever (DHF), Dengue shock syndrome (DSS), Laboratory profile of dengue fever

Full Text:

PDF

References


Gupta N, Srivastava S, Jain A, Chaturvedi UC. Dengue in India. Indian J Med Res. 2012;136(3):373-90.

Special programme for research, training in tropical diseases, and World Health Organization, dengue: guidelines for diagnosis, treatment, prevention and control, World Health Organization, Geneva, Switzerland; 2009.

WHO, dengue and dengue haemorrhagic fever, Factsheet no. 117, World Health Organization, Geneva, Switzerland, 2008. Available at http://www.who.int/mediacentre/factsheets/fs117/en /.

Kabra SK, Jain Y, Pandey RM, Madhulika, Singhal T, Tripathi P, et al. Dengue haemorrhagic fever in children in the 1996 Delhi epidemic. Trans R Soc Trop Med Hyg. 1999;93(3):294-8.

Ratageri VH, Shepur TA, Wari PK, Chavan SC, Mujahid IB, Yergolkar PN, et al. Clinical profile and outcome of dengue fever cases. Indian J Pediatr. 2005;72(8):705-6.

Alam AS, Sadat SA, Swapan Z, Ahmed AU, Karim MN, Paul HK, et al. Clinical profile of dengue fever in children. Bangladesh J Child Health. 2009;33(2):55-8.

Malavige GN, Ranatunga PK, Velathanthiri VG, Fernando S, Karunatilaka DH, Aaskov J, et al. Patterns of disease in Sri Lankan dengue patients. Archives of disease in childhood. 2006;91(5):396-400.

Neeraja M, Lakshmi V, Teja VD, Umabala P, Subbalakshmi MV. Serodiagnosis of dengue virus infection in patients presenting to a tertiary care hospital. Indian J Med Microbiol. 2006;24(4):280.

Ahmed FU, Mahmood BC, Sharma JD, Hoque SM, Zaman R, Hasan MS. Dengue and dengue haemorrhagic fever in children during the 2000 outbreak in chittagong, Bangladesh. Dengue Bulletin. 2001;25:33-9.

Doke P, Pawar S. Profile of dengue fever outbreaks in Maharashtra. Indian J Comm Med. 2000;25(4):170-6.

Dash PK, Saxena P, Abhyankar A, Bhargava R, Jana AM. Emergence of dengue virus type-3 in northern India. Southeast Asian J Trop Med Public Health. 2005;36(2):370.

Kamath S, Jain N, Gupta S, Jha AC, Rao BS. Dengue epidemic in Jamshedpur-Tata Main Hospital (TMH) Experience. J Trop Dise Public Health. 2015:2015.

Srinivasa S, Nawab T, Nair CC. Clinical profile and ultasonogaphic findings in children with dengue fever. Current Pediatric Res. 2014;18(2):87-90.

Prathyusha CV, Rao MS, Sudarsini P, Rao KM. Clinico-haematological profile and outcome of dengue fever in children. Int J Cur Microbiol Appl Sci. 2013;2(10):338-46.

Gomber S, Ramachandran VG, Kumar S, Agarwal KN, Gupta P, Gupta P, et al. Haematological observations as diagnostic markers in dengue hemorrhagic fever-reappraisal. Indian Pediatr. 2001;38:477-81.

Singh S, Meena JK, Verma CR, Bhaskar V. A hospital-based study of hepatic dysfunction in children with dengue fever. Asian Pacific J Trop Dis. 2015;5(12):964-7.

World health Organization. Dengue guidelines for diagnosis, treatment, prevention and control. Geneva: World health Organization; 2009. Available at http://www.who.int/tdr/publications /documents/dengue-diagnosis.pdf. Accessed on 11 November 2015.

World Health Organization. Regional office for Southeast Asia. Comprehensive Guidelines for Prevention and Control of Dengue and Dengue Haemorrhagic Fever. Revised and Expanded Edition. New Delhi: World Health Organization; 2011.