Failure of radical hysterectomy in early invasive cancer cervix: an A. H. regional cancer centre experience

Authors

  • Jita Parija Department of Gynaecologic Oncology, A. H. Regional Cancer Centre Cuttack, Odisha, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20174478

Keywords:

Cancer, Cervix, Radical- hysterectomy, Radiotherapy, Recurrence

Abstract

Background: Early invasive invasive carcinoma of cervix is adequately treated by surgery,radiotherapy or by combination of both.The disease-free and overall survival varies from centre to centre. Recurrence of the disease is a reflection of failure in treatment.

Methods: A total of 541 cases of Radical hysterectomy with pelvic lymphadenectomy, for early stage cancer cervix performed during the period 2006 April - 2017 March at A. H. Regional Cancer Centre Cuttack, were retrospectively analysed, with an objective to identify the risk factors responsible for treatment failure. All cases were followed-up for 5 years or more.

Results: Radiotherapy was supplemented in 27% of cases. Recurrence occurred in 17.18% cases. The incidence of recurrence increased from 13.9% in Stage IB to 26.3% in Stage IIB. Younger patients showed a higher recurrence of 19.16% compared to older group. Poorly differentiated squamous cell carcinoma showed 15.9% recurrence and adenocarcinoma showed 15.38% recurrence. Only 3.7% of recurrence occurred in growths <2cms which increased to 20.6% in tumors >5cms diameter. Infiltrating growths were responsible for treatment failure, recurring in 52.4%. Nodal involvement in >2 groups showed increased recurrence (30%) in contrast to 15.65% in node negative patients. Maximum recurrence occurred in the first year of treatment and beyond three years it looked safe. Adjuvant radiotherapy given in 27%, encountered 18.3% recurrence in comparison to the overall treatment failure.

Conclusions: Age, stage, nature of growth, node-involvement, tumor-bulk and histo-pathological grading, combinedly altered the prognosis in early invasive cervical carcinoma treated with radical hysterectomy and selectively supplemented by radiotherapy.

Author Biography

Jita Parija, Department of Gynaecologic Oncology, A. H. Regional Cancer Centre Cuttack, Odisha, India

Associate Professor ,Department of Gynaecologic Oncology ,Acharya Harihar Regional Cancer Centre , Cuttack , Odisha , India .

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Published

2017-09-28

How to Cite

Parija, J. (2017). Failure of radical hysterectomy in early invasive cancer cervix: an A. H. regional cancer centre experience. International Journal of Research in Medical Sciences, 5(10), 4277–4280. https://doi.org/10.18203/2320-6012.ijrms20174478

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Original Research Articles