DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20174937

Pulmonary function profile of children with sickle cell disease

Mohankumar K. Tambe

Abstract


Background: Lung disease is a major cause of morbidity and mortality in sickle cell disease (SCD). In view of severe anemia, decreased blood oxygen affinity, pulmonary arterial vaso-occlusion, microinfarction and microfibrosis being associated with sickle cell disease; an analysis of pulmonary function in them will be of great interest.

Methods: Seventy 6-12 years old children with SCD (SS pattern) were studied as cases along with age, sex and socioeconomic status matched 70 controls (AA pattern) and comparisons drawn between the two groups.

Results: All the static and dynamic pulmonary functions such as FVC, FEV1, MMEFR25-75%, PEFR and MVV were found reduced in sickle cell disease, most of them significantly.

Conclusions: Any restrictive, obstructive or combined pattern may be produced in SCD depending upon frequency & severity of the acute chest syndrome and vaso-occlusive crises in past.


Keywords


Pulmonary function, sickle cell disease

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References


Wang WC. Sickle cell anemia and other sickling syndromes. In JP Greer et al., eds., Wintrobe's Clinical Hematology, 12th ed: 1038–1082. Philadelphia: Lippincott Williams and Wilkins; 2009.

Kar BC, Devi S, Dash KC, Das M. The Sickle cell gene is widespread in India. Trans Roy Soc Trop Med and Hyg. 1987;81(2):273-5.

Rao VR. Genetics and epidemiology of sickle cell anemia in India. Indian J Med Sci. 1988;42:218-22.

Shukla RN, Solanki BR. Sickle Cell Trait in Central India. Lancet. 1958;1(7015):297-98.

Diggs LW, Barreras L. Pulmonary emboli versus pneumonia in patients with sickle cell anemia. Memphis mid-s-Med J. 1967;42:375.

Fishman AP. Pulmonary diseases and disorders. McGraw Hill Book Company. Second edition. p- 34-6.

Phebus CK, Gloninger MF, Maciak BJ. Growth patterns by age and sex in children with sickle cell disease. Journal of Pediatr. 1984;311:7-12.

Platt OS, Dover GJ. Text book of hematology of infancy and childhood 4th ed. 1995;1:732-40.

Mahajan BK, Gupta MC. Textbook of preventive social medicine and biostatistics. 2nd edition. 1995; P- 414-415; 429-446.

Fung KP, Lau SP, Chow OW, Lee J, Wong TW. Effects of overweight on lung function. Archives of diseases in childhood. 1990;65:512-5.

Marcus CL, Shelly C, Koemer C. Evaluation of pulmonary function and polysomnography in obese children and adolescents. Pediatric Pulmonol. 1996;21:176-83.

Miller GJ, Serjeant GR. An assessment of lung volumes and gas transfer in sickle cell anemia. Thorax. 1971;20:309-15.

Powars D, Deidman JA, Odom-Maryon T. Sickle cell chronic lung disease: Prior morbidity and the risk of pulmonary failure. Medic. 1988;67:66-76.

Pionasi P, D’souza SJ, Charge T, Esseltine DE, Coates AL. Pulmonary function abnormalities in childhood sickle cell disease. J. Pediatrics. 1993;122:366-71.

Nair HR, Kesavchandran C, Sunil R, Sreekumar R, Shashidhar S. Prediction equation for lung function in south Indian children. Indian J Physiol Pharmacol. 1997;41(4):390-6.

Deshpande JN, Dahat HB, Shirole CD, Pande AH. Pulmonary functions and their correlation with anthropometric parameter in rural children. Indian J Pediatrics. 1983;50:375-8.

Wall MA, Platt S, Strider DJ. Lung function in children with sickle cell anemia. American review of respiratory diseases. 1979;120:210-4.

Bowen EF, Crowston JG, Ceulaer KD, Serjeant GR. Peak expiratory flow rate and the acute chest syndrome in homozygous sickle cell disease. Archives of diseases in childhood. 1990;65:330-2.

Bijlani RL. Understanding medical physiology. 2nd edition Jaypee Borthers, New Delhi. 1997;269-70.

Samson Wright. Applied physiology. Edited by Keele, Neil and Joels N. Oxford university press; 1982:157.