Association of duration of type 2 diabetes with short term and working memory

Authors

  • Upneet Bedi Department of Physiology, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India
  • Bavneet Kaur Dang Department of Medicine, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20174643

Keywords:

Diabetes, Duration, Hyperglycemia, Hypoglycemia, Short term memory

Abstract

Background: Type 2 diabetes mellitus has deleterious effects on brain resulting in loss of short term memory and working memory in elderly and poorly controlled diabetic patients. Less attention has been given to the effect of diabetes on cognitive functions. Hence, the study was undertaken to study the status of short term and working memory in type 2 diabetes mellitus and to correlate it with the duration of diabetes.

Methods: Study was conducted in Punjab Institute of Medical Sciences, Jalandhar, India, on 100 diabetic patients in the age group of 40-60 years. Short term memory and working memory was assessed using 4 memory tests. AVLT and VFT for short term memory and WDST and VST for working memory. The results expressed in average of total scores. One-way ANOVA followed by post hoc (t) test were used for statistical analysis.

Results: Short term memory and working memory status was negatively correlated with duration of diabetes. Diabetics more than 55 years showed greater cognitive decline compared to younger age group.

Conclusions: The short term and the working memory status decreased significantly in diabetic patients, which may be due to age of onset, duration, vascular dementia, hyperglycemia or hypoglycemia. These effects observed that duration, sex, age and blood glucose levels are of clinical importance as short term and working memory loss could have important practical implications for daily activities.

References

Kodi CT, Seaquist ER. Cognitive dysfunction and Diabetes Mellitus. Endocr Rev. 2008;29(4):494-511.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5);1047-53.

Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systemic review. Lancet Neurology. 2006;5(1):64-74.

Cukierman-Yaffe T, Gerstein HC, Williamson JD, Lazar RM, Lovato L, Miller ME, et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors; the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial. Diabetes Care. 2009;32(2):221-6.

Ryan CM, Geckle M. Why is learning and memory dysfunction in Type 2 diabetes limited to older adults? Diabetes Metab Res Rev. 2000;16(5)308-15.

Bhagoji SB, Patil M, Mirje M, Shivaprasad. Effect of duration of type 2 diabetes on short term and working memory. Int J Med Pharm Sci. 2014;4(6)26-30.

Naderali EK, Ratcliffe SH, Dale MC. Obesity and Alzheimer’s disease: a link between body weight and cognitive function in old age. Am J Alzheimers Dis Other Demen. 2009;249(6):445-9.

Trushna T, Mohan DS, Nair S, Manjunatha S. A simple screening test with a potential to detect diabetic cognitive impairment in the geriatric population: a preliminary study. Student Medical J. 2011;3(1):17-21.

Rey A. Clinical examination in psychology. Paris: Press Universities de France. 2nd ed, Paris;1964.

Borkowski JG, Benton AL, Spreen O. Word fluency and brain damage. Neuropsycholoia. 1967;5(2):135-40.

Kyllonen PC. Aptitude testing based on information processing: a test of the four sources model. J General Psychology. 1993;120:375-405.

Muangpaisan W, Intalapaporn S, Assantachai P. Digit span and Verbal fluency in patients with mild cognitive impairment and normal subjects in Thai community. J Med Assoc Thai. 2010;93(2):224-30.

Roberts RO, Geda YE, Knopman DS, Christianson TJ, Pankratz VS, Boeve BF, et al. Association of duration and severity of diabetes mellitus with mild cognitive impairment. Arch Neurol. 2008;65(8):1066-73.

Longstreth WT, Bernick C, Monalio TA, Bryan N, Jungreis CA, Price TR. Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the cardiovascular Health Study. Arch Neurol. 1998;55(9):1217-25.

Luchsinger JA, Reitz C, Patel B, Tang MX, Manly JJ, Mayeux R. Relation of diabetes to mild cognitive impairment. Arch Neurol. 2007;64(4)570-5.

Strachan MW, Frier BM, Deary IJ. Type 2 diabetes and cognitive impairment. Diabet Med. 2003;20(1)1-2.

Pelia R, Rodriguez BL, Launer LJ. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study. Diabetes. 2002;51(4):1256-62.

Alencar RC, Cobas RA, Gomes MB. Assessment of cognitive status in patient with type 2 diabetes through a mini mental state examination: a cross sectional study. Diabetology and Metabolic Syndrome. 2010;2:10.

Xu W, Qiu C, Gatz M, Pedersen NL, Johansson B, Fratiglioni L. Mid-and late-life diabetes in relation to the risk of dementia. Diabetes. 2009;58(1):71-7.

Van Harten B, Oosterman JM, Potter van Loon BJ, Scheltens P, Weinstein HC. Brain lesions on MRI in elderly patients with type 2 diabetes mellitus. Eur Neurol. 2007;57(2)70-4.

Den Heijer T, Vermeer SE, Van Dijk EJ, Prins ND, koudstaal PJ, Hofman A, et al. Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetelogia. 2003;46(12):1604-10.

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB. Insulin degrading enzyme regulates extracellular levels of amyloid beta protein by degradation. J Biol Chem. 1998;273(49)32730-8.

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Published

2017-10-27

How to Cite

Bedi, U., & Kaur Dang, B. (2017). Association of duration of type 2 diabetes with short term and working memory. International Journal of Research in Medical Sciences, 5(11), 4724–4727. https://doi.org/10.18203/2320-6012.ijrms20174643

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Original Research Articles